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Lipid Modifying Drugs > Statins (-statin) > Flashcards

Statins (-statin) Flashcards

1
Q

Examples

A

Simvastatin

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2
Q

MoA

A

HMG-CoA reductase
Inhibitor
Prevents conversion of HMG-CoA to mevalonate
Reduces liver synthesis of cholesterol
Increasing Liver uptake of cholesterol from blood

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3
Q

Indications

A

Hypercholesterolaemia

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4
Q

ADR

A 
Myalgia, Myopathy
Rhabdomyolysis
Hepatotoxicity
Myositis
Growing Children
Abnormal LFT
(Increase transaminase)
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5
Q

Prescribing Advice

A

X Itraconazole, Ketoconazole, Posaconazole, Macrolide antibiotics, HIV protease inhibitors (e.g. nelfinavir), Nefazodone, Ciclosporin, Danazol, Gemfibrozil, other fibrates (except fenofibrate), Ca-Channel blockers

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Lipid Modifying Drugs (5 decks)

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