Fibrates Flashcards
1
Q
Example
A
Fenofibrate
2
Q
MoA
A
Nuclear transcription factor PPARalpha esp Liver + Muscle Agonist Increase activity of lipoprotein lipase Decrease synthesis of app C-111 Decrease liver FA oxidation Reduce LDL density Decrease TGs 30-50% Increase HDL 5-15%
3
Q
Indications
A
1st line therapy if TGs >10mmol/L
4
Q
ADR
A
Myositis with statins
Dyspepsia, Gallstones
Increased anticoagulant effects
5
Q
Prescribing Advice
A
X Renal Impairments
