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Lipid Modifying Drugs > Niacin > Flashcards

Niacin Flashcards

1
Q

MoA

A

Inhibit TG lipase
Induce beta oxidation of FAs in liver
Inhibit diacyl-glycerol acyl transferase 2 (DGAT2)
= Prevents esterification of glycerol for TG synthesis
Decreases TGs with secondary result of decreased LDL + VLDL
Increase HDL

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2
Q

Indications

A

Hypertriglyceridaemia

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3
Q

ADR

A

Flushing, Hyperglycaemia
Hyperuricaemia, GI distress
Hepatotoxicity

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4
Q

Prescribing Advice

A

X Renal Impairment

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Lipid Modifying Drugs (5 decks)

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