Statins and Lipid Lowering Drugs II Flashcards
What is the primary prevention for Dyslipidaemia?
Prevents initial cardiovascular event - QRISK assessment.
What is the secondary prevention for Dyslipidaemia?
Prevents secondary cardiovascular event.
What is the purpose of lipid modifying treatments?
Reduce lipid circulating levels.
Slow // Reverse // Prevent the development of atherosclerosis.
Reduce risk of cardiovascular disease.
What do drugs targeting the endogenous pathway affect?
Decreases production in the body.
Increases uptake from bloodstream.
Name the drugs used for targeting the endogenous pathway.
Statins
Fibrates
PCSK9 inhibitors
What do drugs targeting the exogenous pathway affect?
Decreases absorption from dietary sources.
Name the drugs used for targeting the exogenous pathway.
Cholesterol absorption inhibitors
What is the purpose of HMG - CoA reductase?
Inhibits the conversion of acetyl - coA to cholesterol.
LESS cholesterol is made.
What does statins do to plasma concentration alongside cardiovascular events?
Statins reduce both.
What are the side of using statins?
Myalgia
Type II diabetes
Liver Damage
What does fibrates do?
Increases lipoprotein lipase -> increases breakdown of vLDL and chylomicrons.
Thus MORE lipoproteins are broken down.
Name the two drugs which are classed as fibrates.
Bezafibrate
Gemfibrozil
What do PCSK9 do?
Prevents interaction with LDL receptors.
So less is degraded.
What is the purpose of cholesterol absorption inhibitors.
Inhibits absorption of cholesterol in the intestines -> Decreases the total cholesterol and LDL cholesterol levels.
Name the two examples of cholesterol absorption inhibitors.
Ezetimibe
Colestyramine
