Corticosteroids Flashcards
What are corticosteroids?
They are hormones derived from cholesterol and produced in the ADRENAL CORTEX.
What are the main corticosteroids?
- Cortisol
- Aldosterone
What 2 categories of corticosteroids does cortisol and aldosterone split into?
Cortisol = Glucocorticoids Aldosterone = Mineralcorticoids
What is the purpose of corticosteroids?
Lowers inflammation in the body and thus, reduces the immune system activity in the body.
How does cortisol act?
Acts via the glucocorticoid receptors.
How does aldosterone act?
Acts via the mineralocorticoids receptors.
What does cortisol do?
Acts on carbohydrate and protein metabolism.
Regulates host defence mechanisms.
What does aldosterone do?
Regulates water and electrolyte balance.
ESSENTIAL = sodium conservation in the kidney and sweat glands.
Where are glucocorticoids made?
Zona Fasiciculata
Where are mineralocorticoids made?
Zona Glomerulosa
How is glucocorticoid release regulated?
It is regulated by the HPA axis and engages with NEGATIVE feedback control.
What is a competitive inhibitor involved with glucocorticoid release?
Metyrapone
What is the purpose of metyrapone?
Reduces glucocorticoids when there is an OVERLOAD.
This inhibits beta - hydroxylase which INHIBITS cortisol.
What is Cushing’s syndrome?
This is a syndrome which occurs due to excessive levels of endogenous glucocorticoids.
What is Addison’s syndrome?
This is a syndrome which occurs due to very little levels of corticosteroids in the body.