Cyclo - oxygenase Inhibitors Flashcards
What are NSAIDS?
These are a group of medications which relieve pain and fever.
Blocks COX - 2 enzymes.
What are the 3 major therapeutic actions of Cyclo - Oxygenase Inhibitors?
Anti Inflammatory
Analgesic (Pain Relief)
Antipyretic (Fever Relief)
What pathway does NSAIDS inhibit?
Therefore, what step does it INHIBIT?
Lipoxygenase
-> Dioxygenase step is inhibited
What are prostanoids?
This is a hormone like substance which controls the contraction and relaxation of the smooth muscle alongside the dilation and constriction of the blood vessels.
What substance are cycle - oxygenase inhibitors derived from?
Membrane Phospholipids
What is the main therapeutic action of anti - inflammatory drugs?
DECREASE in prostaglandins and prostacyclins.
Vasodilation and Oedema is REDUCED.
What is the main therapeutic action of analgesic drugs?
DECREASE in prostacyclins = REDUCE in sensitisation.
Vasodilation is REDUCED.
What is the main therapeutic action of antipyretic drugs?
DECREASE in prostaglandins = REDUCE temperature.
Name 2 common analgesic drugs.
Naproxen
Celecoxib
Name 2 common anti - inflammatory drugs.
Ibuprofen
Aspirin
Name 2 common antipyretic drugs.
Ibuprofen
Aspirin
What is the difference between COX1 and COX2 in terms of production?
COX1 is produced by a cell in ALL physiological conditions (ALL THE TIME) whereas COX2 is produced by a cell in certain conditions like inflammation (IN TIMES OF NEED).
What is the difference between COX1 and COX2 in terms of location?
COX1 = Kidney // Stomach // Platelets COX2 = Macrophages // Leukocytes // Fibroblasts
What is a structural difference between COX1 and COX2?
COX1 = Isoleucine COX2 = Valine
What is the effect of the COX1 inhibitory enzyme on the GI tract?
Reduces mucus secretion.
Reduces mucosal blood flow.
What is the effect of the COX1 inhibitory enzyme on the kidneys?
Decreases GFR due to REDUCED blood flow.
What is the effect of the COX1 inhibitory enzyme on the cardiovascular system?
INCREASES blood pressure.
What type of inhibitor is paracetamol?
A COX - 3 inhibitor.
Name 2 examples of a selective cox - 2 inhibitor.
Celecoxib.
Etoricoxib.
Give more information about Celecoxib.
Oral medication for pain and inflammation in RA // Osteoarthritis // Spondylitis.
Give more information about Etoricoxib.
Oral medication for pain and inflammation in Osteoarthritis // RA // Acute Gout.
