Cyclo - oxygenase Inhibitors Flashcards
What are NSAIDS?
These are a group of medications which relieve pain and fever.
Blocks COX - 2 enzymes.
What are the 3 major therapeutic actions of Cyclo - Oxygenase Inhibitors?
Anti Inflammatory
Analgesic (Pain Relief)
Antipyretic (Fever Relief)
What pathway does NSAIDS inhibit?
Therefore, what step does it INHIBIT?
Lipoxygenase
-> Dioxygenase step is inhibited
What are prostanoids?
This is a hormone like substance which controls the contraction and relaxation of the smooth muscle alongside the dilation and constriction of the blood vessels.
What substance are cycle - oxygenase inhibitors derived from?
Membrane Phospholipids
What is the main therapeutic action of anti - inflammatory drugs?
DECREASE in prostaglandins and prostacyclins.
Vasodilation and Oedema is REDUCED.
What is the main therapeutic action of analgesic drugs?
DECREASE in prostacyclins = REDUCE in sensitisation.
Vasodilation is REDUCED.
What is the main therapeutic action of antipyretic drugs?
DECREASE in prostaglandins = REDUCE temperature.
Name 2 common analgesic drugs.
Naproxen
Celecoxib
Name 2 common anti - inflammatory drugs.
Ibuprofen
Aspirin
Name 2 common antipyretic drugs.
Ibuprofen
Aspirin
What is the difference between COX1 and COX2 in terms of production?
COX1 is produced by a cell in ALL physiological conditions (ALL THE TIME) whereas COX2 is produced by a cell in certain conditions like inflammation (IN TIMES OF NEED).
What is the difference between COX1 and COX2 in terms of location?
COX1 = Kidney // Stomach // Platelets COX2 = Macrophages // Leukocytes // Fibroblasts
What is a structural difference between COX1 and COX2?
COX1 = Isoleucine COX2 = Valine
What is the effect of the COX1 inhibitory enzyme on the GI tract?
Reduces mucus secretion.
Reduces mucosal blood flow.
