Stars on Dr. Martin's slides

Question 1

What level do we find blood pressure control?

Answer 1

arterioles

Question 2

How can AVMs be caused by an arterial aneurysm?

Answer 2

it can rupture into a nearby vein

Question 3

Who is most susceptible to fibromuscular dysplasia?

Answer 3

young women

*string of beads due to abnormal smooth m. deposition

Question 4

What qualifies someone with malignant HTN?

Answer 4

BP >200/>120

*renal failure, retinal hemorrhages, papilledema

Question 5

Arterial wall response to injury

Answer 5

1. chronic endothelial injury
2. endothelial dysfunction
3. macrophage activation, smooth m. recruitment
4. macrophages and smooth muscle cells engulf lipid (foam cells, fatty streaks)
5. smooth muscle proliferation, collagen, and other ECM depiction, extracellular lipid

Question 6

Arthersclerosis weakens what part of the media? HTN? tertiary sphyilis?

Answer 6

a. inner media
b. outer media
c. outer media

Question 7

What is obliterative endarteritis?

Answer 7

characteristic of tertiary syphilis –> predilection for small vessels (including vasa vasorum of thoracic aorta) –> ischemic injury of the aortic media and aneurysmal dilation (can can involve aortic valve regurgitation)

Question 8

AAA is typically due to? TAA?

Answer 8

a. atherosclerosis

b. HTN

Question 9

What is the origin of a gloms tumor (glomangioma, paraganglioma)?

Answer 9

smooth muscle cells