Cholinergic DSA Flashcards
Direct acting cholinomimetics
- acetylcholine
- bethanechol
- carbachol
- cevimeline
- methacholine
- pilocarpine
- varenicline
Cholinesterase inhibitors
Ambenonium Donepezil Echothiophate Edrophonium Galantamine Neostigmine Physostigmine Pyridostigmine Rivastigmine Tacrine
Cholinesterase regenerator
Pralidoxime
Tolterodine
Trospium
Drugs used for cholinergic poisoning
atropine (+ pralidoxime)
Cholinesterase regenerator
Drugs used for movement disorders
benztropine
biperiden
Cholinesterase regenerator
Drugs used for motion sickness
scopolamine
Antimuscarinic drugs
Drugs used for GI disorders
Atropine
Dicyclomine
Glycopyrrolate
Hyoscyamine
Antimuscarinic drugs
Drugs used in ophthalmology
Atropine Cyclopentolate Homatropine Scopolamine Tropicamide
Antimuscarinic drugs
Drugs used for respiratory disorders (asthma, COPD)
Ipratropium
Tiotropium
Antimuscarinic drugs
Drugs used for urinary disorders
Darifenacin Fesoterodine Oxybutynin Solifenacin Orphenadrine Procyclidine Trihexyphenidyl
Antimuscarinic drugs
Ganglion blockers
mecamylamine
Why do we give choline esters orally?
- you don’t
- they are poorly absorbed orally
Patient presents with poisoning from eating a wild mushroom. What’s going on?
- muscarine is poisonous when ingested, and crosses BBB
How do direct acting cholinergic agonists affect skeletal muscle?
- eventually leads to flaccid paralysis if sustained at site for too long
- ONLY nAChRs affected
All parasympathetic cardiac actions are mediated by…
M2
- small agonist dose: decrease PVR, initial decrease in BP (goes back up due to baroreceptors)
- large dose: bradycardia
