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Afsha NEW CV > stable angina > Flashcards

stable angina Flashcards

1
Q

what is stable angina

A
  • predictable chest pain/pressure, often precipitated by physical exertion or emotional stress which causes increase in myocardial oxygen demand
  • relieved within a few mins of resting
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2
Q

stable angina usually results from

A

atherosclerotic plaques in coronary arteries which restrict blood flow and oxygen supply to heart

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3
Q

describe the pain in stable angina

A
  • typically occurs in front of chest
  • can spread to neck, jaw, left arm, shoulder
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4
Q

complications of stable angina

A
  • unstable angina
  • stroke
  • MI
  • sudden cardiac death
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5
Q

Prinzmetals or vasospastic angina

A
  • rare form of angina, not caused by atherosclerosis
  • caused by narrowing or occlusion of proximal coronary arteries due to spasm
  • pain is experienced at REST
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6
Q

how to treat acute attacks of stable angina

A
  • sublingual GTN
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7
Q

How to use sublingual GTN for the treatment of angina

A
  • one tab/1-2 sprays under tongue and close mouth
  • dose may be repeated at 5 min intervals if needed
  • seek urgent medical care if symptoms not resolved 5 mins after second dose, or earlier if pt unwell/pain is intensifying
  • max 3 doses
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8
Q

how to use sublingual GTN for angina prophylaxis

A

1 tablet/400–800 micrograms to be administered under the tongue and then close mouth prior to activity likely to cause angina.

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9
Q

long term prevention of chest pain in pt with angina

A
  1. BB (or RL-CCB instead)
  2. dual therapy of BB + any CCB licensed (if they are taking BB, prescribed DHPN CCB e.g. amlod, felod, MR nifed)

avoid verap + BB same time - significant interaction, increased risk adverse CV events

  1. if either BB or CCB cannot be given, add vasodilator as dual therapy (LA nitrate, ivabradine, nicorandil, ranolazine)
  2. if both BB and CCB can’t be given, vasodilator mono therapy (LA nitrate, ivabradine, nicorandil, ranolazine)
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10
Q

4 BB that are licensed for angina long term treatment - PBAM

A

propranolol
bisoprolol
atenolol
metoprolol

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11
Q

Can you give BB in Prinzemtal’s angina

A

no it is contraindicated! give RL-CCB instead e.g. verapamil or diltiazem
DHPRDN-CCB e.g. amlodipine may also be effective

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12
Q

What is used for treatment of Prinzmetals angina

A

NOT BB they are contraindicated!!

RL CCB or DHPDN CCB e.g. amlodipine

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13
Q

MOA nitrates

A
  • potent coronary vasodilators
  • reduce venous return to heart, thus reduce LV work (blood pumped out by heart) = less CO = less strain on heart
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14
Q

Examples of vasodilators that can be used in angina long term prevention therapy (e..g if a BB or CCB not suitable)

A

Long acting nitrate (e.g. isosorbide mono/dinitrate), ivabradine, nicorandil, ranolozine

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15
Q

Cautions nitrates - long acting or transdermal preps

A
  • many pt taking these quickly develop tolerance
  • constant levels of nitrates in blood = body becomes desensitised
  • progressively higher dose needed for same therapeutic effect
  • to overcome, choose dose timings that leave blood nitrate free or with very low levels for 4-12 hours everyday
  • e.g. remove patches for 8-12h (e.g. overnight)
  • when a LA nitrate taken BD, take 2nd dose after 8 h instead of 12 hours so it doesn’t cover a 24h period
  • MR isosorbide mononitrate to be taken OD
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16
Q

SE of nitrates

A
  • vasodilators: flushing, throbbing headache, postal hypotension
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17
Q

interactions of nitrates

A
  • SE if hypotension, so taking two or more drugs = increased risk of hypotension
  • e.g. antihypertensives, alpha blockers, BBs, antidepressants, antipsychotics, diuretics, SGLT2i (e.g. canag)
  • e.g. SEVERE, avoid phosphodiester-type 5 inhibitors (e.g. sildenafil)
18
Q

when to assess response to treatment

A
  • every 2-4 weeks after initiation or change of drug therapy
  • titrate drug doses to max tolerated effective dose
19
Q

when to refer to specialist

A
  • combination of two drugs at max therapeutic doses fail to control angina symptoms
20
Q

does having angina put you at increased risk of CV events

A

yes

21
Q

secondary prevention of CV events

A
  • lifestyle factors e.g. smoking cessation, weight management, increase physical activity
  • all pt with arable angina due to atherosclerotic disease should be given long term treatment with lose dose aspirin + statin
    consider ACEi also esp if pt has diabetes
22
Q

how long does the effects of sublingual GTN last

A

provides rapid symptomatic relief, but effect only lasts 20-30 mins

23
Q

expiry of sublingual GTN tablets

A

8 weeks after opening!!

24
Q

MHRA nicorandil

A

ulcers of mouth, mucosa, GI, eyes
cans lead to perforation, haemorrhage, abcsess etc
if ulcers occur, stop treatment and consider alternative

25
Q

name 3 long acting nitrates

A
  • GTN patches
  • isosorbide dinitrate MR (BD), isosorbide mononitrate BD
  • MR isosorbide mononitrate OD
26
Q

what type of drug is nicorandil

A

vasodilator

27
Q

Non drug treatment that should be considered for patients with stable angina who remain symptomatic whilst on optimal drug therapy

A

revascularization by coronary artery bypass graft or percutaneous coronary intervention

28
Q

Drugs for secondary prevention of CV disease (4)

A

Consider aspirin 75mg daily, taking into account risk of bleeding and comorbids

Consider ACEi for people with stable angina and diabetes

Offer stain treatment

Offer treatment for hypertension

29
Q

Reviewing drug treatment - how often

A

Review pt response to treatment, including any SE, 2-4 weeks after starting or changing drug treatment

Titrate drug dosage against pt symptoms up to max tolerated dose

30
Q

when to consider adding a 3rd anti anginal drug - only in the following situation!

A

Symptoms not satisfactory controlled with 2 anti anginal drugs AND

Pt waiting for recvascualrisation or revascularisation is not considered appropriate or acceptable

Decide which one to use based on comorbids, contraindications, pt pref and drug costs

31
Q

Important note with ranolazine - it can cause the following

A

QT prolongation. So avoid with other drugs that cause this!

e.g. hypokalaemia: theophylline, b2 agonists, CCs, amphotericin B, loop and thiazide diuretics
e.g. QT interval: amiodarone, antipsychotics, apomorphine, citalopram, escitalopram, erythromycin , fluconazole, hydroxyzine, sotalol

32
Q

avoid grapefruit juice with

A

ranolazine, other CCBs, ivabradine

it increases the exposure

33
Q

max dose simvastatin with ranolazine

A

20mg

34
Q

ivabradine can only be used in treatment of agina in pt with

A

normal sinus rhythm

35
Q

ivabradine - avoid drugs that can increase the risk of

A

TDP
Also avoid potent inhibitors eg clarithromycin

36
Q

monitoring for ivabradine

A

Monitor regularly for atrial fibrillation (consider benefits and risks of continued treatment if atrial fibrillation occurs).

Monitor for bradycardia, especially after any dose increase, and discontinue if resting heart rate persistently below 50 beats per minute or continued symptoms of bradycardia despite dose reduction.

37
Q

important counselling info about nicorandil re a specific side effect (not ulceration)

A

headache more common on initiation
usually transitory

if they are suscepible to this, use lower inital dose regimen

38
Q

Patient comes in complaining of stomach pain, they say they think it is a bad case of reflux. They also mention that they have got a few ulcers in their mouth that they want to buy bonjela for. They mention they are on medication for angina.

You tell them to stop taking this particular medication and urgently refer them to their GP. What medicine was it?

A

nicorandil

Nicorandil can cause serious skin, mucosal, and eye ulceration; including gastrointestinal ulcers, which may progress to perforation, haemorrhage, fistula or abscess. Stop treatment if ulceration occurs and consider an alternative.

39
Q

which CCBs are licensed for angina. both RL and DHPDN

A

verapamil and diltiazem
nifedipine, nicardipine, amlodipine, felodipine

40
Q

which drugs are CI if you take ivabradine etc

A

antipsychotics, amiodarone, apomorphine, citalopram, dronedarone, fluconazole - TDP - avoid

erythromycin, clarithromcyin - TDP and increases exposure to ivrabradine, avoid

Afsha NEW CV (40 decks)

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