dyslipidaemias BNF Flashcards
what is 1st line for treating hypercholesterolaemia and moderate hypertriglycerideaemia
statins
what can you give to pt with severe hypercholesterolaemia or hypertriglyceridaemia not adequately controlled with max dose of statin
+ additional lipid regulating drug e.g. ezetimibe
generally supervised by specialist
what are pt with familial hypercholesterolaemia at high risk of
premature CHD
give life long lipid modifying therapy and advice on lifestyle changes
1st line for pt with familial hypercholesterolaemia
high intensity statin (dose at which reduction of LDL-C >40% is achieved)
titrate dose to achieve a reduction in LDL-C >50% baseline
Patients with primary heterozygous familial hypercholesterolaemia who have contra-indications to, or are intolerant of statins, can be considered for treatment with
ezetimibe monotherapy
what is recommended if the maximum tolerated dose of a statin alone fails to provide adequate control of LDL-cholesterol, or a switch to an alternative statin is being considered. (for familial hypercholesterolaemia)
statin + ezetimibe
what can be considered under specialist advice, in patients for whom statins or ezetimibe are inappropriate. (for familial hypercholesterolaemia)
fibrate or bile acid sequestrant (e.g. colestyramine, colestipol
Do not use this combination as it increases the risk of rhabdomyolosis considerably
gemfibrozil + statin
other fibrates can be used with statin, but under specialist as they increase risk of muscle related SE
these two -mabs can be considered for pt with primary heterozygous familial hypercholesterolaemia whose LDL-cholesterol has not been adequately controlled on maximum tolerated lipid-lowering therapy
Alirocumab and evolocumab
