SSRIs

Question 1

List the SSRIs (5)

Answer 1

1. Citalopram
2. Fluoxetine
3. Paroxetine
4. Sertraline
5. Fluvoxamine

Question 2

What do the SSRIs treat?

Answer 2

First line for major depression; also tx for anxiety disorders (panic, OCD, ADHD)

Question 3

Drug drug interactions?

Answer 3

SSRI + MAOI –> Serotonin syndrome.. Dont do it!

Question 4

Drug drug interactions?

Answer 4

SSRI + MAOI –> Serotonin syndrome.. Dont do it!

Question 5

Do SSRIs have a high of low TI?

Answer 5

High (lower OD risk)

Question 6

ADEs of SSRIs? (3)

Answer 6

1. Sexual dysfunction
2. GI (N/V)
3. Teratogen (especially Paroxetine)

Question 7

Describe serotonin syndrome?

Answer 7

Hyperthermia, confusion, myoclonus, CV collapse, flushing, diarrhea, seizures (First aid)
Class: increase 5HT1A receptors in midbrain central grey

Question 8

How do you get serotonin syndrome?

Answer 8

• First Aid: Anything that increases serotonin: SSRI, MAOI, TCA
• Class: also amphetamine/NMDA, LSD, buspirone, L-Tryptophan

Question 9

How to treat serotonin syndrome?

Answer 9

Cyproheptadine (5HT2 antagonist).. First Aid