Anti-psychotics: Atypical

Question 1

What are the atypical (2nd generation) antipsychotics?

Answer 1

1. Clozapine
2. Risperidone
3. Olanzapine
4. Quetipaine
5. Ziparsidone
6. Aripirazole
7. Paliperidone

Question 2

General MOA of atypical antipsychotics?

Answer 2

D2 receptor antagonists: effective for decreasing positive symptoms
Anti-5HT2A: effective for decreasing negative symptoms

Question 3

Which atypical antipsychotics have low potency & low EPS and high anticholinergic?

Answer 3

Clozapine, Olanazopine, Quetiapine

Question 4

Which one decreases EPS at low doses but increases EPS at high doses?

Answer 4

Risperidone

Question 5

DOC in children/teens?

Answer 5

Risperidone

Question 6

Which one is a D2 partial agonist, a 5HT1 partial agonist, and a 5HT2 antagonist?

Answer 6

Aripiprazole (lower ADEs cuz of partial agonist)

Question 7

Which one is 5HT1A, HT2A, HT2C and D2 antagonist?

Answer 7

Ziprasidone

Question 8

Which one is D1, D2, alpha adrenergic, histaminergic, and 5HT1/2 receptor antagonist?

Answer 8

Asenapine

Question 9

Which one is D2 antagonist, 5HT2A antagonist, 5HT1A partial agonist w/ increased risk for EPS?

Answer 9

Lurasidone