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Psych Pharm > MAOIs > Flashcards

MAOIs Flashcards

1
Q

What are the MAOIs? (3)

A
  1. Tranylcypromine
  2. Phenelzine
  3. Isocarboxazid
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2
Q

Indications for MAOIs?

A

Rarely used; only in its unresponsive to other drugs/ECT

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3
Q

MAOI MOA?

A

Irreversibly inhibits MAO-A and MAO-B in nerve terminals.

  • MAO-A: metabolizes NE, 5HT, tyramine
  • MAO-B: metabolizes DA
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4
Q

PK of MAOI?

A
  • Acetylators (susceptible to pharmacogenomics)

- Long duration of drug effects

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5
Q

Clinical effects of MAOIs?

A

Acute: CNS stimulation & euphoria
Chronic: clinical symptoms improve but CNS stimulation remains

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6
Q

Drug drug interactions?

A
  • Tyramine (Cheese).. Watch out for depressed person at a wine & cheese party –> sudden malignant HTN
  • Meperidine/Dextromehorphan: high temp, delirium, death
  • SSRI, Cocaine
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7
Q

ADE of MAOI? (4)

A
  1. Decreased sleep
  2. Orthostatic hypotension
  3. Weight gain
  4. Sexual dysfunction
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Psych Pharm (10 decks)

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