Anti-Psychotics: Typical Flashcards
(8 cards)
What is responsible for the positive symptoms of psychosis?
Dopamine
Whats responsible for the neg symptoms of psychosis?
Serotonin
What are the typical anti psychs? (1st gen)
- Phenothiazines: Chlorpromazine, Fluphenazine
- Thioxanthenes: Thiothixene
- Diphenylbutylpiperidines: Haloperidol
MOA of typicals?
- D2 receptor antagonists –> decrease positive symptoms
- Secondary anti-D2 effect: increase prolactin
- Anti-cholinergic: decrease EPS
What is Chlorpromazine’s unique structural feature?
Aliphatic side chain –> lower potency, less risk for EPS, more risk for anti-cholinergic
What is Thiothixene’s unique structural feature?
Piperidine side chain –> lower potency, lower risk for EPS, more risk for anti-cholinergic
Fluphenazine, Perphenazine unique structural features?
Piperazine group side chain –> higher potency, more risk for EPS, decreased risk for anti-cholinergic
Butyrophenones (Haloperidol) potency? EPS risk? Anticholinergic?
high, high, low