spinals & epidurals Flashcards
from superficial to deep, what are the ligaments
interspinous ligament, ligamentum flavus, posterior longitudinal ligament, anterior longitudinal ligament
piercing the ___ contributes to the loss of resistance when the needle enters the epidural space
ligamentum flavum
midline approach passes thru which 3 ligaments
surpaspinous, interspinous, ligamentum flavum
paramedian approach passes thru
ligamentum flavum
an epidural hematoma accumulates between the ___ and the ___
dura bone
epidural space is located between?
ligamentum flavum and dura mater
subdural space is located between?
dura mater and arachnoid mater
subarachnoid space is located between?
arachnoid mater and pia mater
how many cervical vertebra
7 (c1-c7)
how many thoracic vertebra?
12
how many lumbar vertebra
5
how many sacral vertebra
5
how many coccygeal vertebra
4
LA’s are bases or acids?
weak bases
esters have __ structure
c-o-c
amides have __ structure
N-h
agents with a ___ pka value will have a ___ onset
lower , faster. because a greater fraction of molecules will exist in the uncharged form, this will more easily diffuse across nerve membranes
the ___ form of an LA is most lipid soluble and is able to gain access to the axon
uncharged
mechanism of LA’s
block nerve conduction by impairing propagation of the action potential in axons
LA’s ___ the rate of rise of the action potential such that threshold potential is not reached
decrease
does the unionized form of the drug work while inside the cell?
no! it becomes ionized once inside
LA’s work ___cellularly
intra.
agents with a high degree of protein binding will have a ___duration
prolonged
pka determines __ of onset of neural blockade
speed
which fibers are more easily blocked, thin or thick??
thin.
which fibers are more readily blocked, myelinated or unmyelinated?
myelinated
what plays the greatest role in conduction speed of a nerve fiber
diameter / myelinaton
which fibers are the biggest
A
which fibers are the smallest
C
A alpha
skeletal muscle - motor. and proprioception
A beta
touch pressure proprioception
a gamma
skeletal muscle tone
a delta
fast pain, temp and touch
B fibers act where? myelinated?
pre-ganglionic ANS fibers. light myelination
C fibers are myelinated?
NO
C fiber sympathetic function
postganglionic ANS fibers
C fiber dorsal root function
slow pain, temp, touch.
which fibers are blocked first
B
which fibers are blocked second
c
which fibers are blocked last
A - gamma/delta, then alpha/beta
sequence of block
ATP-TP-MVP
ATP-TP-MVP
autonomic, temp, pain, touch, pressure, motor, vibration, proprioception
b fibers are __ sized and ___ myelinated
small , lightly
how are esters metabolized
plasma cholinesterase break them down in the blood
how are amides metabolized
in the liver
what is basicity
density relative to the desntiy/ specific gravity of CSF
hypobaric will ___ while hyperbaric will
float, sink
addition of water makes a solution ___
hypobaric
addition of dextrose makes a solution
hyperbaric
addition of epi to an LA will ___ the risk of systemic toxicity
decrease. it decreases the rate of absorption, thus minimizing peak blood levels of LA’s
epi ___ the intensity of a block
increases
how does epi effect the duration of anesthesia
prolongs
when would you not add epi?
areas with poor circulation (fingers toes penis), beir block, htn, CAD, arrhythmia, hyperthyroid, utero-placental insufficiency
how does sodium bicarb affect spinal
raises the ph and increases the conc of non-ionized base, which increases the rate of diffusion across the nerve membrane and speeds the onset of blockade.
addition of fentanyl to LA ___ onset, ___ level , and ___ duration
shortens, increases, prolongs
action of opioids is ___ with LA’s
synergistic
amide allergic reaction is caused by
methyl paraben preservative
ester allergic reaction is caused by
PABA (metabolite )
number one contraindicatio to a spinal is
patient refusal
if you threaten someone into something it is ___, if you actually do it, its ____
assault, battery