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ABPN > spiegel 2 > Flashcards

spiegel 2 Flashcards

1
Q

carbamazapine induces

A

CYP 2C19 and 3A4
including 3A4:
erythromycin
clarithromycin
alprazolam
diazepam
midazolam
cyclosporine
indinavir
ritonavir
saquinavir
diltiazem
nifedipine
amlodipine
verapamil
atorvastatin
simvastatin
aripiprazole
burpspirone
haloperidol
tamoxifen
trazodone
propranolol
zolpidem
zaleplon
methadone
estradiol
progesterone
testosterone
fentanyl
many more.

2C19:
amitriptyline, citalopram, clomipramine, imipramine, warfarin, propranlool, primidone

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2
Q

Essential Tremor rxs

A

B blockers (propranolol)
Benzo (clonazepam, lorazepam)
Botulinum toxin A

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3
Q

migraine chromosome

A

19

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4
Q

CNS cysticercosis

A

invasion of brain by T. solium. (undercooked pork)
Various presentations include epilepsy, focal neuro deficits, hydrocephalus, cognitive decline, meningitis, myelopathy.

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5
Q

most frequent neurological complication of chronic alcohol abuse

A

alcoholic neuropathy

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6
Q

miller-fisher syndrome

A

variant of guillain barre:
gait ataxia, areflexia, ophthalmoplegia

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7
Q

cortical vs subcortical dementia

A

cortical- e.g. Alzheimers. Slow progressive decline, aphasia, dyspraxia, agnosia
subcortical- e.g. Parkinson’s. dysarthria, Extrapyramidal motor abnormalities, apathy, depression

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8
Q

buspar moa

A

serotonin 1A partial agonist

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9
Q

excitatory neurotransmitters moa

A

open cation channels that depolarize the cell membrane and increase the likelihood of generating an action potential.

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10
Q

PCP moa

A

NMDA antagonist

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11
Q

sublimation

A

a mature defense. Obtaining gratification through transforming a socially unacceptable aim into an acceptable one.

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12
Q

phenelzine moa

A

MAO-I

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13
Q

Anna Freud

A

wrote The Ego and Mechanisms of Defense
gave first comprehensive study of defense mechanisms
maintained that all people used some

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14
Q

Sigmund Freud

A

father of psychoanalysis
focused on libido, aggression, Oedipal complex

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15
Q

Kohut

A

father of self-psychology

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16
Q

Fromm

A

defined 5 character types common to WEstern culture

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17
Q

Jung

A

founded analytic psychology; growth of the personality through one’s experiences

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18
Q

3rd nerve palsy

A

Diabetes vs aneurysm
eyelid ptosis, pain, diplopia
diabetes- pupil size normal
aneurysm- dilated

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19
Q

lesch nyhan deficiency?

A

hypoxanthine-guanine phosphoribosyltransferase

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20
Q

APO E4 what chromosome?

A

nineteen

21
Q

tricyclic with most antihistamine activity

A

doxepin

22
Q

action potential

A

First ion channel to open: Na+, flows into the neuron
Ca2+ opens, allowing MORE positive ions to enter.
then Ca2+ act as messengers- critical to the release of neurotransmitter and activate the opening of K+ channels which put a stop to the action potentio through the afterhyperpolarization of the membrane.

23
Q

abreaction

A

emotional release after recalling a painful event. Part of psychodynamic therapy

24
Q

opiates and pupils

A

pinpoint- using (high)

25
Q

least sedating trycyclics

A

desipramine and protriptyline

26
Q

REM sleep disorder predictive of

A

Lewy Body

27
Q

Tourette’s common comorbid with

A
  1. ADHD
  2. OCD
  3. CD
28
Q

Mahler’s stages

A

0-2 mos autism (sleep more than awake)
2-5 mos symbiosis
5-10 mos differentiation
10-18 mos practicing (independence)
18-24 mos rapprochement
2-5 years object constancy (people are permanent)

29
Q

primary auditory cortex

A

superior temporal gyrus (Heschl’s)

30
Q

adjunctive neurotransmitter at NMDA (binds with glutamate) and independent inhibitory neurotransmitter
negative symptoms of schizophrenia?
receptors on spinal cord

A

glycine

31
Q

mee’s lines under nails caused by

A

arsenic poisoning

32
Q

blue line at the gums from

A

lead poisoning

33
Q

most common congenital viral infection newborns

A

CMV

34
Q

Most common myopathy over 50

A

inclusion body myositis

35
Q

rate-limiting enzyme in dopamine synthetic pathway

A

tyrosine hydroxylase

36
Q

benzos, alcohol, and barbituates target

A

GABA-A

37
Q

Ganser’s syndrome

A

rare dissociative disorder characterized by nonsensical or wrong answers to questions and other dissociative symptoms such as fugue, amnesia or conversion disorder, often with visual pseudohallucinations and a decreased state of consciousness.[1] The syndrome has also been called nonsense syndrome, balderdash syndrome, syndrome of approximate answers, hysterical pseudodementia or prison psychosis.

38
Q

increases lithium levels significantly

A

ibuprofen

39
Q

the 3-hydroxys with no metabolities

A

L-O-T

40
Q

for aggression in ID, prisoners, schizophrenia

A

lithium

41
Q

benign neonatal convulsins caused by

A

K channels

42
Q

poor prognosis in guillain barre

A

camp jejuni

43
Q

cause of apoptosis in brain

A

NMDA recpeptors overstimulated–> calcium influx

44
Q

Kluver Bucy

A

stroke to amygdaloid bodies and inferial temporal cortex –> hypersexual, placid, hyper oral

45
Q

alogia

A

poverty of speech and thought content

46
Q

Bowlby

A

separation response in kids:
- protest
- despair & pain
- detachment and denial of affection

47
Q

time for RLS dx

A

3 months

48
Q

rx lithium toxicity

A

hemodialysis

49
Q

NEVER with MAOI

A

meperidine

ABPN (6 decks)

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