specific PK examples

Question 1

what is TMPT

Answer 1

Thiopurine-S methyl transferase

Question 2

what does TMPT do

Answer 2

meatbolses thiopurine

Question 3

what is scc

Answer 3

succhinylchone, it is a nueromuscular blocker

Question 4

what enzyme breaks down SCC

Answer 4

butyrylchonlineesterase

Question 5

what teh different vairants in scc

Answer 5

heterozygoius- 3x4 longer paralysis
homozygous- 3-4 hrs
silent- np cholineastease actvity

Question 6

What gene has polymorphisms in alchohol metabolism

Answer 6

CY2C19

Question 7

What gene has polymorphisms for wafarin

Answer 7

CYP2C9

Question 8

What gene has polymorphisms in nortryptiline

Answer 8

CYP2D6

Question 9

what cuases too fast metbaolism of alchohol

Answer 9

ald1b*2

Question 10

what is achohol metablised too

Answer 10

acetaldehyde

Question 11

what causes toxic build ups from alchool methabolims and wehat does it lead to

Answer 11

aldh2*2
head and enck cancer

Question 12

what causes ultra metbaolisers

Answer 12

gene amplification

Question 13

what cab you do with TMPT treatment

Answer 13

you can screen for SNPs

Question 14

what warafin variinats are they and what are there acxtivty

Answer 14

CYP2C92- 40% as affective
CYP2C93- only 10% affectove
patients wih both varinast 2-3x more likely to bleed out