specific PD examples

Question 1

what is the antimalaria drug

Answer 1

primaquine

Question 2

what is the defiecy that affects the antimaaria drug and what does it do

Answer 2

G-6-PD
causes haeolyisis of blood cells

Question 3

waht does G-6-PD defiecny do

Answer 3

meake suspecxtible to ROS as primaquine is an oxidant

Question 4

what polymorphic componenant affects warafirn

Answer 4

vit k epoxidase reuctsae compartment 1

Question 5

what are the different wafarin metabolisers

Answer 5

haploytype A - lower dose
hapotype B - higher dose

Question 6

what depefct can lead to maligant hyperthermia

Answer 6

defects in ryanodine repecptor

Question 7

what drug cause the maligant hypertehrmia

Answer 7

hylogenated anathetics and succhinylcholineesterase

Question 8

how does the drugs normally bind and how does it form malogant hyoerthermia

Answer 8

the muscle membrane ion channels noramlly bind the ryanodine and then ca is released. with the defect the ca os constantly re;eased leadiing to constant muscle contraction which leads to enegry dleption and msucle death