Sources of Drugs Flashcards
Oldest source of drugs used empirically
leaves, seeds, flowers, roots, bark, etc.
NATURAL
Different Sources of Drugs
Natural
Semi-Synthetic
Synthetic
Types of Natural Drugs
Plants
Animals
Minerals
Metals, metalloids, non-metal substances and their compounds
Minerals
When the nucleus of drug obtained from natural source is retained but the chemical structure is altered
Semi-Synthetic
Done in pharmaceutical laboratory
Organic or inorganic or combination of both compounds
Synthetic
Involves cleavage of DNA by enzyme restriction endonucleases
Recombinant DNA technology
Problems of Plants used as drugs.
Identification of plant Climatic and social conditions of area Season of collection Condition of storage Standardization of active principle Purity of active ingredient Maintenance of supply line Active principle is synthesized after detection
Types of drugs under plants
Leaves Flowers Fruits Roots Seeds Bark
VARIOUS FORMS OF PLANT DRUG
Extract, infusions, decoction, powders, etc.
Chemicals (alkaloids, glycosides, oil, resins, tannins, gums etc.) isolated from different forms are used for humans and animals
Examples of Minerals
iron, calcium, magnesium, aluminum, sodium, potassium, sulphur, lithium
Examples of Semi-Synthetic Drugs
6-aminopencillanic acid (fungus), semi-synthetic human insulin (pork insulin)
Examples of Synthetic Drugs
chloroform, ether, nitrous oxide, chloral hydrate
Examples of Recombinant DNA
Human insulin, human proinsulin gene to form insulin
Growth hormone, tissue plasminogen activator, vaccines, interferon, erythropoitins, G-colony stimulating factor