Drugs for Lower RT Flashcards
Bronchodilators Steroids Leukotriene Modifiers Mast Cell Stabilizers Expectorants Antibiotics
Agents used for COPD
Medications used to facilitate respirations by dilating the airways
Bronchodilators
used to decrease inflammation
Steroids
reduce inflammation in the lung tissue
Leukotriene Modifiers
act as anti-inflammatory agents by suppressing the release of histamine from the mast cells
Mast Cell Stabilizers
are used to assist in loosening secretions from the airway
Expectorants
are prescribed to prevent serious complications from bacterial infections
Antibiotics
Helpful in symptomatic relief or prevention of bronchial asthma and for bronchospasm associated with COPD
Bronchodilators
Types of bronchodilators
Xanthines
Sympathomimetics
Anticholinergics
Inhaled Steroids
Aminophylline Oxtriphylline Theophylline Pentoxifylline Caffeine
Types of Xanthines
have a direct effect on the smooth muscles of the respiratory tract, both those on the bronchi and the blood vessels
Xanthines
Stimulate the CNS such that respiration is stimulated, coronary arteries and pulmonary arteries dilate, with additional effects of diuresis
Xanthines
Indicated for the symptomatic relief or prevention of bronchial asthma and reversal of bronchospasm associated with COPD
Indications of Xanthines
GI upset, anorexia, vomiting, gastric pain, seizures, brain damage, and even death
Adverse Effects of Xanthines
cause dizziness, flushing, severe hypotension, bradycardia, and palpitations
Adverse Effects of Aminophylline
drugs mimic the effects of the sympathetic nervous system; dilation of the bronchi and increased rate and depth of respiration
Sympathomimetic drugs
Albuterol Bitolterol Isoproterenol Metaproterenol Salbutamol Terbutaline Ephedrine Epinephrine
Different kinds Sympathomimetic Drugs:
Asthma
Bronchospasm
Exercise induced bronchospasm
Preterm Labor
Clinical Use of Sympathomimetic
Cardiac disease vascular problems Arrhythmias Diabetes Hyperthyroidism Pregnancy, and lactation
Contraindications of Sympathomimetic
tremors, headache, nervousness GI upset cardiac arrhythmias, hypertension, tachycardia, palpitations, vasoconstrictions bronchospasm, sweating, pallor, flushing Hyperglycemia Urinary retention
Adverse Effects of Sympathomimetic
Beclomethasone Flunisolide Triamcinolone Dexamethasone Prednisone prednisolone
Different kinds Inhaled Steroids:
Decreased swelling associated with inflammation
Promotion of beta adrenergic receptor activity, which may promote smooth muscle relaxation and inhibit bronchoconstriction
Inhaled Steroids
Not for emergency use
Not for use during an acute asthma attack or status asthmaticus
Pregnancy and lactation
Contraindications of Inhaled Steroids
Sore throat, hoarseness, coughing, dry mouth, pharyngeal and laryngeal fungal infections
Adverse Effects of Inhaled Steroids
A newer class of drugs developed to act more specifically at the site of the problem associated with asthma.
Leukotriene Receptor Antagonists
Referred to as anti-inflammatory bronchoconstriction preventers
Leukotriene Receptor Antagonists
Montelukast (Lukast, Montekast)
Zafirlukast (Accolate)
Zileuton
Different Kinds of Leukotriene Receptor Antagonists
works on the immune system at the cellular level.
MoA of Leukotriene Receptor Antagonists
30 minutes
Onset effect of Leukotriene Receptor Antagonists
Peak effect of Leukotriene Receptor Antagonists
3-4 hours
Duration effect of Leukotriene Receptor Antagonists
24 hours
hepatic or renal impairment
Pregnancy and lactation
Contraindications of Leukotriene Receptor Antagonists
Headache Dizziness Myalgia Nausea Diarrhea Abdominal pain Elevated liver enzymes Vomiting Generalized pain Fever
Adverse Effects of Leukotriene Receptor Antagonists
Prevents the release of inflammatory and bronchoconstricting substances when the mast cells are stimulated to release these substances because of irritation or the presence of an antigen.
Mast Cell Stabilizers
cromolyn (Intal)
nedocromil (Tilade)
Types of Mast Cell Stabilizers
type of mast cell stabilizer for the treatment of chronic bronchial asthma, exercise-induced asthma, and allergic rhinitis
cromolyn (Intal)
Type of mast cell stabilizer for the management of mild to moderate bronchial asthma
nedocromil (Tilade)