Sos- Tauopathy Flashcards
Cognitive genetic disorders
tauopathies
Dementia with ______ is almost as common as alzheimers
lewy bodies
Microtubule associated protein that stabilizes the microtubules
Tau
____becomes mutated and collect and polymerize (inside of neurons and it kills the neurons)
Tau
Movement disorder and cognitive loss and it gets worse with time
Tauopathy
The longer you live, the greater percent chance you will have ____ or _____
Tauopathy or Alzheimers
sulci widening
ventricular dilation
parenchymal loss
gross pathology of Alzheimer’s
L
Alzheimer’s
loss of Ach (acetylcholine)
loss of nucleus basalis
Alzheimer’s
loss of neurons from the locus ceruleus; decrease in serotonin
Alzheimer’s
amyloid beta deposits
neurofibillary tangles
Alzheimer’s
neurofibrillary tangles (tau)
Amyloid plaque
abnormal clipping of APP (amyloid protein)
Amyloid plaque
amyloid plaques
neurofibrillary tangle (Tau tangle)
granulovacuolar degeneration and amyloid angiopathy
early onset alzheimers
50s
late-onset alzheimers
> 65 yrs
Atrophy of the cerebral cortex and the basal ganglia
Symptoms begin in the 60s, initially unilateral onset
(looks like Alzheimers)
Corticobasal degeneration
basal ganglia degeneration
corticobasal degeneration
50s
Personality change (classic)
Pick’s disease
Pick’s disease
cells and bodies (in neurons) and affects hippocampus (short term memory)
Pick’s disease
found in hippocampus
Pick’s (bodies) cells
someone with longstanding uncontrolled HTN; lacunar infarcts
strokes
microvascular degeneration in white matter
