Lopez- Eye Flashcards
what eye
patient’s L eye
diabetic retinopathy
caused by tiny clumps or strands of gel-like collagen fibers in vitreous humor; clumps cast shadows on retina
floaters
leading cause of blindness in working-age adults
diabetic retinopathy
risk factors:
poor glycemic control
HTN
dyslipidemia
diabetic retinopathy
in ______ diabetic retinopathy, retinal ischemia stimulates release of VEGF (vascular endothelial growth factor)
proliferative diabetic retinopathy
due to capillary leakage and occlusion; microaneurysms and cotton wool spots and dot-blot hemorrhages seen
nonproliferative diabetic retinopathy
white, fluffy lesions on retina caused by blockage or reduced perfusion in retinal arterioles; damaging ganglion cells and accumulation of proteins in nerve fiber layer
cotton-wool spots
chronic retinal ischemia triggering VEGF overexpression; neovascularization and fibrous tissue growth (increases risk of retinal detachment)
proliferative diabetic retinopathy
microaneurysms
hemorrhage
nonproliferative diabetic retinopathy
retinal hemorrhages
cotton-wool spots
hard exudates
proliferative diabetic retinopathy
retinal detachment
Flashes of light in the peripheral field of the left eye
photopsia
Dark specks moving across his field of vision.
floaters
A progressive shadow (“curtain”) in the upper portion of his left visual field
field loss
______is the separation of the neurosensory retina from the underlying retinal pigment epithelium (RPE), leading to progressive vision loss and potential blindness if untreated
retinal detachment
a retinal tear or break referred to as ___
rhegma
due to retinal tear, fibrous tissue tungs retina off, or subretinal fluid from tumors/inflammation
pathophys of retinal detachment
retinal detachment
The detachment interrupts the connection between the retina and its blood supply (choroid), leading to ischemia and _____ death
photoreceptor
retinal detachment
C
what causes increase in VEGF during proliferative diabetic retinopathy
chronic hyperglycemia causes capillary damage and then ischemia
peripheral vision loss
retinitis pigmentosa
_____ help us see at night
rods
rare genetic disorder that involves the degeneration of the retina
Retinitis Pigmentosa
Usually presents in adolescence or young adulthood; mutations in photoreceptor proteins (rods)
Retinitis Pigmentosa
central vision loss
drusen
age-related macular degeneration
metamorphopsia
most common cause of blindness in this country
age>65, smoking, caucasian, FH, poor diet
age-related macular degeneration
yellowish extracellular deposits of lipids and proteins that accumulate between the Bruch’s membrane (part of the choroid) and the retinal pigment epithelium (RPE)
drusen
due to accumulation of drusen and photoreceptor loss (cones)
dry age-related macular degeneration
due to choroidal neovascularization
vascular leakage and hemorrhage
fibrosis and scar formation
wet age-related macular degeneration
Chronic hypoxia and inflammation stimulate the release of vascular endothelial growth factor (VEGF), promoting the growth of abnormal, fragile blood vessels from the choroid through Bruch’s membrane into the retina
choroidal neovascularization
detects metamorphopsia
Amsler grid
drusen accumulation around macula
dry age-related macular degeneration
hemorrhage
central vision loss
drusen
wet age-related macular degeneration
central retinal artery occlusion
central retinal vein occlusion
usually due to embolism (by Afib)
acute ischemia of retina due due to artery occlusion
retinal artery occlusion
painless sudden monocular vision loss
cherry red spot on macula
retinal artery occlusion
due to venous stasis or compression
thrombus in central retinal vein
central retinal vein occlusion
hypercoagulable states can increase risk for this
central retinal vein occlusion
“blood and thunder retina”
painless, sudden monocular vision loss
central retinal vein occlusion
cherry red spot
pale retina
central retinal artery occlusion
“blood and thunder” appearance
diffuse retinal hemorrhages
central retinal vein occlusion
lysosomal storage disorder due to deficiency in beta-hexosaminidase A
accumulation of gangliosides
cherry red spot on macula
Tay-Sachs
due to chronic effects of HTN
hypertensive retinopathy
AV nicking!!!!!
copper wiring
hemorrhages
cotton wool spots
papilledema (in HTN emergency)
hypertensive retinopathy
AV nicking and copper wiring
hypertensive retinopathy
indicates malignant HTN
papilledema
hypertensive retinopathy
hypertensive retinopathy
papilledema
malignant HTN
retinoblastoma
Most common primary intraocular malignant tumor in children, usually one eye
retinoblastoma
caused by mutation in RB1 tumor suppressor gene
retinoblastoma
Leukocoria (white pupillary reflex)
Strabismus
seen in child’s eye
retinoblastoma
“cat’s eye reflex”
retinoblastoma
calcifications and rosettes
retinoblastoma
Flexner-Wintersteiner rosettes
retinoblastoma
most common intraocular malignant neoplasm in adults
Uveal (choroid) melanomas
Risk factors include caucasians with blue or green eyes, UV light exposure and dysplastic nevus syndrome
Uveal (choroid) melanomas
Uveal nevus (eye freckle)
Uveal (choroid) melanoma
spindle-like cells
melanoma
stain for melanoma
HMB-45
swelling of optic disc
papilledema
Most commonly due to increased CSF pressure transmitted to the optic nerve head by the CSF surrounding the optic nerve, can also be due to tumors within the optic nerve
papilledema
pailledema
_____ flow is from the ciliary body in the posterior chamber to the anterior chamber draining into the channel of Schlemm
aqueous humor
caused by decreased drainage of aqueous humor through the channel of Schlemm
open-angle glaucoma
caused by obstructed flow of aqueous humor and be acute causing severe pain and vision loss
close-angle glaucoma
diffuse loss of ganglionic cells
cupping of optic disc
glaucoma causing optic nerve damage
retina is thin (loss of ganglionic cells) due to what
glaucoma
opacification of the lens
cataract
Risk factors include age, lifestyle choices, diabetes, trauma and infection (accumulation of stuff within the lens)
cataract
B
B
A
B