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Physical Pharmacy > Solids > Flashcards

Solids Flashcards

1
Q

Characteristics of Solids

A
  • Strong intermolecular forces of Attraction
  • Little kinetic energy
  • Incompressible
  • Fixed/definite shaoe
  • Little translational motion
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2
Q

Types of Solids

A

Crystalline
Amorphous
Polymeric

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3
Q

Arranged in repititious 3-dimensional lattice units

A

Crystalline Solids

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4
Q

Crystalline solids

A

Definite melting points
With 7 common lattice units/unit cell
Anisotropic

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5
Q

Cubic

A

NaCl

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6
Q

Tetragonal

A

Urea

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7
Q

Orthorhombic

A

Ritonavir (Form II)

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8
Q

Rhombohedral

A

Iodine

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9
Q

Hexagonal

A

Iodoform

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10
Q

Monoclinic

A

Sucrose

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11
Q

Triclinic

A

Boric Acid

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12
Q

Amorphous Solid is also called as

A

“Glasses” or “Supercooled Liquids”

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13
Q

Amorphous Solid

A
  • Randomly arranged particles
  • No ordered long-range structure
  • Non-crystalline; no definite order
  • Have no definite & sharp melting points
  • isotropic
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14
Q

Large molecules formed by the covalent assembly of smaller molecules into a chain or network of repeating structural unitd

A

Polymeric/Polymers

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15
Q

The number of repeating units in the polymer determines its ________ and _______

A

The number of repeating units in the polymer determines its molecular weight and size of polymer

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16
Q

Polymers are used as ________ in solid, semisolid, and liquid formulations

A

Polymers are used as excipients in solid, semisolid, and liquid formulations

17
Q

Types of Polymers

A

Natural Polymers
Synthetic and Semisynthetic

18
Q

Natural polymers

A

Rubber (Polyisoprene)
Polypeptides
Cellulose (Polysaccharide)

19
Q

Synthetic & Semisynthetic Polymers

A

PVP
Polyethylene
Polystyrene

20
Q

LMW PEG

A

Co-solvent for solution formulations

21
Q

HMW PEG

A

Ointment and Suppository Base

22
Q

Ability to exist in more than one crystalline form

A

Polymorphism

23
Q

Polymorphism is due to changes in

A

Intermolecular bonding patterns
Molecular orientation difference

24
Q

Polymorphs have different properties

A

Melting point
Solubilities
Stability
X-ray diffractions

25
Q

Cocoa butter polymorphic form

A

Unstable gamma: 18°C
Alpha: 22°C
Beta prime: 28°C
Beta stable: 34.8°C

26
Q

Polymorphic forms of Tamoxifen citrate

27
Q

Polymorphic forms of Famotidine

28
Q

Polymorphic forms of Phenytoin

29
Q

Polymorphic forms of Indomethacin

30
Q

Reversible change from one polymorphic form to another

A

Enantiotropic Polymorphism

31
Q

Polymorphism that has irreversible change and one polymorph is thermodynamically stable

A

Monotropic Polymorphism

Physical Pharmacy (14 decks)

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