Chemical Kinetics

Question 1

Study of the rates of reactions & the mechanism by which these reactions occur

Answer 1

Chemical Kinetics

Question 2

Velocity with which the reaction occurs

Answer 2

Rate of Reaction / Degradation Rate

Question 3

Rate of Reaction / Degradation Rate depends on:

Answer 3

• Reactant concentration
• Temperature
• pH
• Presence of solvents or additives

Question 4

The way in which the concentration of the drug or reactant in a chemical reaction affects the rate

Answer 4

Order of Reaction

Question 5

The drug concentration changes with respect to time at a constant rate

Answer 5

Zero-Order Reaction

Rate of reaction is independent of the concentration of the reactants

Question 6

The rate of reaction is dependent on the concentration of drug remaining

Answer 6

First-Order Reaction

Question 7

Zero Order

Answer 7

• Constant Amount
• Independent
• Conc/time
• t1/2: Variable
• Theophylline, Aspirin, Phenytoin, Ethanol

Question 8

First-Order

Answer 8

• Constant fraction
• Dependent
• Per time
• Constant t50

Question 9

The period of time required for the amount or concentration of a drug to decrease by one-half or 50%

Answer 9

Half-life

Question 10

The period of time where 90% of the original concentration is left & 10% is already degraded

Answer 10

Shelf-life

Question 11

Zero-Order Formula

Answer 11

Formula: C = -kt + C0
T1/2: 0.5 * C0/k
Shelf-life: 0.1 * C0 / k
Units of K: Concn/time

Question 12

First Order Formula

Answer 12

Formula: -kt + lnc0
T1/2: 0.693/k
Shelf-life: 0.105/k
Units of K: per time