Solar dermatitis Flashcards

Questions made based on SAD p659-667 and Yen's R&R notes

You may prefer our related Brainscape-certified flashcards:
1
Q

Name 7 Ddxs for this

A

Solar dermatitis

Dermatophytosis

Notoedric mange

Fight wounds

Vasculitis

Frostbite or cryoglubulinemia

DLE, SLE

PE, PF

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2
Q

Match

UVA

UVB

UVC

<290 nm

290-320 nm

320-400 nm

A

UVA 320-400 nm

UVB 290-320 nm

UVC <290 nm

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3
Q

True/False

UVA wavelength penetrates deeper into the skin than UVB

A

True

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4
Q

Which UV spectrum is associated with phototsensitivity reactions?

A

UVA

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5
Q

What wavelength is most damaging to the skin?

A

320-340 nm

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6
Q

What are chromophores?

A

Light absorbing molecules

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7
Q

Name the chromophores in the skin

A

Keratin proteins, blood, hemoglobin, porphyrin, carotene, nucleic acids, melanin, lipoproteins, pepitde bonds and aromatic amino acids (such as tyrosine, tryptophan and histidine)

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8
Q

What are the natural UVL barriers in the skin?

A

Stratum corneum, melanin, blood, and carotenes

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9
Q

What is the difference between photosensitivity and photo toxicitiy?

A

Photosensitivity = when the skin has increased susceptibility to the damagin effects of UVL because of the production, ingestion, injection of, or contact with photodynamic agent

Photo toxicity = CLASSIC sun burn reaction; dose related response to light exposure

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10
Q

True/False

Solar dermatitis is a photo toxic and photo sensitivity reaction

A

False

Solar dermatitis is purely a photo toxic reaction (sunburn) and has no apparent relationship to a hypersensitivity state

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11
Q

Name the skin structures involved in photo toxicity

A

Epidermis and blood vessels of the superficial and deeper vascular plexus

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12
Q

What are sun burn cells?

A

Vacuolated keratinocytes post exposure to UVB / UVC

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13
Q

Name the changes that occur in the skin after UVB and UVC exposure

A

Vacuolated keratinocytes in the superficial epidermia, apoptotic KCs, vascular dilatation and leakage, depletion of Langerhans and mast cells

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14
Q

What are the oxygen intermediates that may be important in the pathogenesis of solar damage?

A

Superoxide radical, hydrogen peroxide and hydroxyl radical

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15
Q

What do oxygen intermediates do?

A

Deplete antioxidants, recruits neutrophils and can destroy connective tissue

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16
Q

What is the initial lesion in canine nasal solar dermatitis?

A

Erythema and scaling of non pigmented skin

17
Q

Name 7 DDx for this (facial dermatosis)

A

DLE, SLE, dermatomyositis, epidermolysis bullosa, PF, PE, drug reaction, infectious folliculitis and furunculosis due to bacteial, dermatophyte, Demodex, yeast or leishmanial infection

18
Q

What is solar elastosis?

A

Basophilic degeneration of elastin

19
Q

What special stain is needed to highlight solar elastosis?

A

PAS stain

20
Q

The damaging effects on cutaneous immunity of UVB is mediated by which cytokine?

A

TNF-a

21
Q

Clinically, how would you differentiate solar dermatitis vs photosensitivity?

A

Photosensitivity occur in well-haired regions of the body (light color)