fluoroquinolones

Question 1

Why it is important to dose fluoroquinolones high?

Answer 1

The mutant selection window hypothesis states that picking a dose between the MIC (which will inhibit colony formation of 99% of the most susceptible bugs) and the Mutant Prevention Concentration (the mic of the most resistant strain), creates selection pressure for resistant bacteria.

Best AUC/MIC ratio with marbofloxacin and enrofloxacin as well as ciprofloxacin (in vitro but questionable absorption. ( Awji et al. Vet derm. 2012)