sodium Flashcards
What’s the most abundant, osmotically important extracellular cation?
sodium
accounts for 86% of plasma osmolality
disorders of sodium are associated with increased mortality & length of hospital stay
How to assess a hyponatremic pt? how to manage?
ENDOCRINOLOGiST should guide Ix & management of hyponatremia
History:
symptoms (non-specific, frequently hyponatremia is an incidental finding (symptoms uncommon with serum sodium [] >125mmol/L: nausea, headache, vomiting, confusion, muscle cramps- in severe cases, seizure & coma)
Medical issues (eg. diarrhoea/vomiting, Addison’s, cirrhosis, heart failure, renal failure, hyperproteinaemia)
medications/drugs (eg. AEDs, PPIs, diuretics, antibiotics, SSRIs)
drinking habits
Examination:
if severe: hyporeflexia, confusion/drowsiness/reduced GCS, seizures, coma
volume status (HR, BP incl postural hypoT, skin turgidity, evidence oedema)
signs of other disease processes that may be associated
Investigations:
urea
electrolytes
paired (serum & urine) osmolalities & urinary sodium
-If the pt is hypervolaemic & the urinary sodium is low (<20mmol/L), it means increased interstitial salt (Ddx incl cirrhosis, CCF). If urine Na+ >20mmol/L, DDx= cerebral salt wasting, renal failure, diuretics.
-if ECF volume normal, consider water intoxication/primary polydypsia, hypothyroidism, hypotonic fluids (if low urine osmolality) or SIADH if urine osmolality normal or high (normally excess water would result in urine osmololity <100mOsmol/kg) since SIADH causes inappropriate water retention (eg. CNS, malignancy)- other Ddx if urine osmolality higher= glucocorticoid insufficiency.
-If ECF volume decreased & low urinary sodium, pre-renal (eg. diarrhoea, sweat, burns, SBO), while urine Na+ >20mmol/L is renal (eg, renal failure, Addison’s) or drugs (eg. diuretics)
-factitious: hyperglycaemia/lipidaemia/proteinaemia/glycine washout for TURP or hysteroscopy
urine dip (proteins, ketones)
blood glucose
TSH
ACTH
cortisol
consider other Ix depending on findings: short synacthen, ECG, CXR, abdo US, CT head/thorax/abdo/plevis, echo
Rx:
specific Rx depends on the cause
restore normal sodium & water balance in a well0controlled monitored environment
At what rate should sodium be increased?
maximum 4-6mmol/24hrs, 12-14mmol/L per 48hrs, 14-16mmol/L per 72hrs, to reduce risk myelinolysis
best managed in critical care environment with art line
endocrinologist should guide Ix & management of hyponatremia
What are the classifications of hyponatremia?
Mild: 130-135mmol/L
moderate 125-129mmol/L
severe <=125mmol/L
may be hypertonic (dilutional), isotonic (pseudohyponatremia), hypotonic hypervolaemic, euvolaemic, hypovolaemic)
What’s normal ECF sodium? total body sodium content? daily requirement?
134-146mmol/L
58mmol/kg
2mmol/kg
How to estimate osmolality (mosmoles/kg of solvent)?
2x (Na + K) + glucose + urea (mOsm/kg)
What’s normal serum osmolality? what change in osmolality may stimulate water reabsorption? what does hypovolaemia stimulate?
280-290mosmol/kg
increase in ECF osmolality as small as 1-2% may stimulate the posterior pituitary to relate ADH which stimulates V2 receptors on distal nephron to increase water reabsorption via aquaporin-2 channels.
thirst is also stimulated
renin secretion (from renal JG cells) is stimulated due to hypovolaemia. Renin converts angiotensinogen to angiotensin I which, via ACE, is converted to angiotensin II, stimulating adrenal cortex to release aldosterone.
renal cortex also detects decreased plasma sodium, stimulating aldosterone secretion, a mineralocorticoid which acts on principal cells in CDs to increase Na reabsorption (& water via osmosis) & also causes sodium absorption from sweat, saliva & colon.
What’s normal urine osmolality?
50-1400 mOsmol/kg
What are the 3 basic mechanisms through which someone can develop hyponatremia?
- gaining excess water in isolation (eg, SIADH, dextrose infusion)
- gaining water in excess of gaining Na+ (eg. liver failure, CCF, nephrotic syndrome)
- sodium depletion to a greater extent than water depletion (renal: cerebral salt wasting syndrome, diuretics. non-renal: GI losses, sweat losses, “3rd space” (burn, pancreatitis, trauma)
examples of hypotonic hypovolaemic hyponatremia?
diarrhoea
vomiting
sweat
burns
pancreatitis
trauma
if urine Na+ >40mmol/L, consider:
Addison’s
cerebral salt wasting syndrome
diuretics
*may be >1x so important to exclude other pathologies eg. hypothyroidism
examples of hypotonic euvolaemic hyponatremia?
SIADH
hypothyroidism
glucocorticoid insufficiency
hypotonic fluids
drugs (diuretics, PPIs, AEDs, antibiotics, SSRIs)
examples of hypotonic hypervolaemic hyponatremia?
cirrhosis
heart failure
nephrotic syndrome
renal failure
pregnancy
examples of isotonic pseudohyponatremia?
hyperlipidaemia
hyperproteinaemia (multiple myeloma & recent immunoglobulin therapy)
examples of hypertonic dilutional hyponatremia?
severe hyperglycaemia
glycine washout (TURP, hysteroscopy)
mannitol
What’s the short synacthen test?
test of adrenal insufficiency
measure serum cortisol before & after injection of synthetic ACTH