SNRIs, MAOIs, thyroid hormones, and novel agents Flashcards
what are the three most commonly used SNRIs
duloxetine
venlafaxine
sdesvenlafaxine
Brand name of milnacipran
Savella
Band name of levomilnacipran
fetzima
Name all 5 SNRIs
Duloxetine
venlafaxine
desvenlafaxine
milnacipran
levomilnacipran
brand name of duloxetine
cymbalta
brand name for venlafaxine
effexor
brand name for desvenlafaxine
pristiq
which SNRIs cause increased sweating
duloxetine
venlafaxine
dosage range for duloxetine
30-120mg daily in 1-2 doses
FDA approved uses for duloxetine
MDD
peripheral neuropathy
fibromyalgia
GAD
musculoskeletal pain
geriatric considerations for duloxetine
lower doses
labs to monitor with duloxetine
BP
LFTs
baseline creatinine
pregnancy risk of duloxetine
low
which SNRIs must be tapered to dc
duloxetine
venlafaxine
desvenlafaxine
what conditions would cause you to avoid duloxetine
angle-closure glaucoma
heavy alcohol use
severe renal/hepatic impairment
which SNRI decreases the effectiveness of narcotic pain medications
duloxetine
interaction between duloxetine and THC
THC decreases concentration of duloxetine
which SNRIs increase bleeding risk when taken with NSAIDs, ASA, or anticoagulants
duloxetine
venlafaxine
dosage range for ER venlafaxine
37.5-225 qd
what considerations are there with dosing IR venlafaxine
divided in 2-3 doses
max is 375mg
FDA approved uses for venlafaxine
depression
GAD
social phobia
panic disorder
geriatric considerations with venlafaxine
lower doses
caution with cardiovascular disease
labs to monitor for venlafaxine
baseline creatinine
pregnancy risk for venlafaxine
low
when would you avoid venlafaxine
angle-closure glaucoma
venlafaxine dosage with renal/hepatic impairment
decrease by 50%
dose related side effects of venlafaxine
increased BP and HR
dosage range for desvenlafaxine
50-100mg qd
FDA-approved uses for desvenlafaxine
MDD
Which geriatric conditions should you be cautious with desvenlafaxine
caution with CV disease, HTN, liver/renal failure, glaucoma
labs to monitor for desvenlafaxine
baseline creatinine
pregnancy risk of desvenlafaxine
low
desvenlafaxine effect on UDS
false positive for PCP and amphetamines
contraindications for desvenlafaxine
angle-closure glaucoma
MAOIs
ETOH abuse
CNS depressants
desvenlafaxine dosage adjustment for renal impairment
50mg qd for moderate
50mg qod for severe
desvenlafaxine dosage adjustment for hepatic impairment
max 100mg qd
FDA approved indications for venlafaxine
MDD
GAD
social anxiety
panic disorder
FDA approved indications for desvenlafaxine
MDD
off-label indications for venlafaxine
OCD
ADHD
panic disorder
depression w/ cocaine addiction
chronic pain
most common SE of venlafaxine and desvenlafaxine
nausea