Antipsychotics Flashcards
1
Q
brand name for aripiprazole
A
abilify
2
Q
brand name for brexpiprazole
A
rexulti
3
Q
brand name for cariprazine
A
vraylar
4
Q
brand name for chlorpromazine
A
thorazine
5
Q
brand name for clozapine
A
clozaril
6
Q
brand name for iloperidone
A
fanapt
7
Q
brand name for haloperidol
A
haldol
8
Q
brand name for lurasidone
A
latuda
9
Q
brand name for lumateperone
A
caplyta
10
Q
brand name for olanzapine
A
zyprexa
11
Q
brand name for paiperidone
A
invega
12
Q
brand name for quetiapine
A
seroquel
13
Q
brand name for risperidone
A
risperidol
14
Q
brand name for ziprasidone
A
geodon
15
Q
weight gain with aripiprazole
A
low risk
16
Q
dosage of aripiprazole for mania and schizophrenia
A
10-30 mg qd
17
Q
dosage of aripiprazole for augmenting SSRI/SNRI
A
2-10mg qd
18
Q
FDA approved uses for aripiprazole
A
irritability in autism
schizophrenia
acute/mixed mania
bipolar maintenance
acute agitation
19
Q
off label uses for aripiprazole
A
bipolar depression and behavioral issues
20
Q
labs to montir with aripiprazole
A
fasting lipids
fasting glucose
CBC
BMI
21
Q
which enzymes metabolize aripiprazole
A
3A4
2D6
22
Q
which mood stabilizers decrease concentration of aripiprazole
A
carbamazepine
valproate
23
Q
weight gain with brexpiprazole
A
more weight gain/sedation than abilify
24
Q
dosage of brexpiprazole for schizophrenia
A
1-4mg
25
what enzymes metabolize brexpiprazole
2D6
3A4
26
dosage of brexpiprazole for depression
2-4mg
27
FDA approved uses for brexpiprazole
schizophrenia
tx resistant depression
28
off label uses for brexpiprazole
bipolar depression
acute/mixed mania
29
geriatric considerations for brexpiprazole
not with dementia
30
what labs should be monitored with all antipsyhotics
fasting lipids
fasting glucose
CBC
BMI
31
brexpiprazole side effects v. aripiprazole side effects
brexpiprazole has more weight gain but less GI side effects
32
max dose of brexpiprazole in renal impairment
3mg
33
weight gain with clozapine
high
34
upwards clozapine taper
25mg QHS and then increase by 25-50mg q48-72 hours
35
when do you start obtaining trough plasma levels for clozapine
at 200mg
36
FDA approved uses for clozapine
treatment resistant schizophrenia
reduce SI in schizophrenia
37
additional labs to monitor with clozapine for the first month
troponin and CRP weekly
38
how often should you obtain absolute neutrophil counts with clozapine
weekly x 6 months
q2 weeks x6 months
monthly thereafter
39
contraindications for clozapine
myeloproliferative disorder
paralytic ileus
uncontrolled epilepsy
CNS depression
40
severe side effects of clozapine
severe neutropenia
agranulocytosis
myocarditis
41
how can you prescribe clozapine
must be on national registry
42
what are the biggest advantages to clozapine
most effective
TD is rare
decreases SI
43
dosage for asenapine
5-10mg SL BID
44
FDA approved uses for asenapine
negative sx of schizophrenia
bipolar 1
45
which antipsychotic can be used for prn and why
asenapine d/t its fast absorption
46
asenapine and QT interval
2-5 second QT prolongation
47
asenapine drug interactions
nicotine
decreases effectiveness of narcotic pain killers
48
which meds are contraindicated with asenapine
buspirone
vilazodone
49
starting dosage of iloperidone
2mg BID
50
dosage range for iloperidone
12-24mg in divided doses
51
FDA approved uses for iloperidone
schizophrenia
52
off label uses for iloperidone
bipolar maintenance
tx resistant depression
53
what are geriatric considerations for all antipsychotics
lower doses
increased risk of death
increased risk of CVA
54
what is an advantage of iloperidone
TD is rare
55
when would you avoid iloperidone
hepatic impairment
severe cardiac impairment
56
dosage of lurasidone for schizophrenia
40-80mg QHS
57
dosage of lurasidone for bipolar
20-60mg QHS
58
FDA approved uses for lurasidone
schizophrenia
bipolar depression
59
off label uses for lurasidone
tx resistant depression
60
what is the preferred antipsychotic to use when taking a pregnant woman off a mood stabilizer
lurasidone
61
which antipsychotics have to be tapered down slowly
lurasidone
paliperidone
ziprasidone
62
which antipsychotic has to be taken with 350 cal of food for absorption
lurasidone
63
weight gain with lumateperone
25% lose weight
64
dose for lumateperone
42mg qd
65
FDA approved uses for lumateperone
schizophrenia
bipolar depression
66
pregnancy considerations for lumateperone
not during lactation
67
black box warning on lumateperone
dementia related psychosis and suicidality
68
side effect profile of lumateperone
low EPS and negative sx
69
weight gain with olanzapine
high weight gain
70
PO dosage range for olanzapine
5-20mg qd
71
FDA approved uses of olanzapine
schizophrenia
acute/mixed mania
bipolar maintenance
acute agitation
72
when is olanzapine used for treatment resistant depression
in combination with fluoxetine
73
off label uses for olanzapine
combine with naltrexone or metformin for metabolic side effects
74
gender difference in dosage of olanzapine
women may need lower doses
75
contraindications for olanzapine
angle-closure glaucoma, unstable medical condition
76
advantages of olanzapine
high efficacy for class
low QTc issues
77
olanzapine dosage considerations for hepatic/renal impairment
start low IM for renal
hepatic start w/ 5mg and get yearly LFTs
78
general dosage range for paliperidone
6-12mg qd
79
dosage range for paiperidone with sustenna
39-324 monthly
80
dosage of paliperidone with trinza
273-819 q3 months
81
FDA approved uses for paliperidone
schizophrenia
schizoaffective disorder
bipolar
82
what must you remember when starting IM paliperidone
start with PO first then switch over
83
major disadvantage to paliperidone side effects
dose-dependent EPS
hyperprolactinemia
84
contraindications for paliperidone
other meds than prolong QT interval
hx of arrhythmia
recent MI
preexisting severe GI narrowing
85
paliperidone dosage adjustment for renal impairment
mild = max dose of 6mg
mod-severe = max dose 3mg
86
weight gain with quetiapine
moderate weight gain
less with ER formulation
87
dosage range for quetiapine
150-800mg qd
88
FDA approved uses for quetiapine
schizophrenia, mania, bipolar maintenance, adjunct for depression
89
quetiapine dosage adjustment for elderly
25-100mg BID
90
which antipsychotic is preferred for parkinson's psychosis and lewy body dementia
quetiapine
91
which mood stabilizer does quetiapine interact with
depakote
92
weight gain with risperidol
moderate
93
initial dosage and titration of risperidone
1mg qd divided in 2 doses then increase by 1mg daily
94
dosage range for risperidone
2-8mg
95
FDA approved uses for risperidol
schizophrenia
other psychotic disorders
acute/mixed mania
bipolar maintenance
irritability in autism
96
risperidone dosage adjustment for elderly
0.5mg intially then 1mg BID
97
additional labs to monitor with risperidone
prolactin levels
EKG
98
risperidone dosage adjustment for renal/hepatic impairment
0.5mg in divided doses (0.25mg BID) x1 week then 0.5mg BID
99
what dosage does risperidone have a high risk of EPS
>6mg
100
weight gain with ziprasidone
less weight gain
take with food
101
dosage of ziprasidone for schizophrenia
20-40mg BID
max 200mg qd
102
dosage of ziprasidone for bipolar
initial 40mg BID
max 160mg qd
103
FDA approved uses for ziprasidone
schizophrenia
acute/mixed mania
bipolar maintenance
acute agitation
104
which 2 antipsychotics prolong QT interval the most
paliperidone
ziprasidone
105
what antipsychotics have to be tapered to dc
ziprasidone
lurasidone
paliperidone
106
contraindications for ziprasidone
other QT prolongating meds
hx QTc prolongation or arrhtythmia
HF
MI
107
which atypical antipsychotics have the most weight gain
olanzapine
clozapine
108
indications for clozapine other than previous tx failures
severe TD
low threshold for EPS
109
which antipsychotics are approved for bipolar maintenance
aripiprazole
olanzapine
quetiapine
110
which antipsychotics are used to tx aggression and self-injury in children
risperidone
olanzapine
111
which receptors does risperidone have antagonist action
5HT2A
D2
a1-adrenergic
a2-adrenergic
H1
112
common side effects of risperidone
weight gain
anxiety
N/V
rhinitis
ED
anorgasmia
increased pigmentation
sedation
113
which enzyme metabolizes risperidone
2D6
114
risperidone with SSRIs
marked elevation in prolactin levels
115
recommended dosage of risperidone
6mg NTE 12mg daily
116
which antipsychotics are available in depot
risperidone
paliperidone
olanzapine
117
what enzymes is olanzapine a substrate for
1A2
2D6
118
what cannot be coadministered with olanzapine
benzodiazepines
119
quetiapine is a substrate for which enzyme
3A4
120
which antipsychotic is not associated with EPS
seroquel
121
what med increases seroquel clearance 5 fold
phenytoin
122
which enzyme metabolizes geodon
3A4
123
absorption when geodon is taken with food
doubled
124
which enzymes metabolize clozapine
mainly 1A2
less by 2D6 and 3A4
125
WBC that contraindicates clozapine
<3500
126
which enzymes metabolize iloperidone
2D6
3A4
127
what enzyme metabolizes lurasidone
3A4
128
which enzymes metabolize lumateperone (Caplyta)
1A2
3A4
129
how long should you leave the stabilization dose the same after an acute episode of psychosis
3-6 months
