SNP's

Question 1

CYP1A2

Answer 1

Caffeine metabolism r/t risk of heart attack (CYP450 family)

Question 2

CYP3A4

Answer 2

drug metabolism (CYP450 family)

Question 3

CYP19A1

Answer 3

aromatase / synthesis of estrogen (CYP450 family)

Question 4

VDR

Answer 4

vitamin D binding

Question 5

BCO1/BCMO1

Answer 5

beta carotene conversion to active vitamin A

Question 6

MTHFR

Answer 6

detoxification & folate metabolism

Question 7

COMT

Answer 7

detoxification and catecholamines

degrades dopamine, epinephrine, and norepinephrine

Mg dependent (supplement to “speed up” COMT)

Fast COMT - get rid of dopamine too quickly; low levels of all 3 catecholamines (supplement with quercitin to slow down)

also methylates estradiol (makes it less active in preparation for breakdown) - slow COMT - less efficient breakdown of estradiol - increased risk of

Question 8

ACE

Answer 8

salt-sensitive hypertension

Question 9

APOE4

Answer 9

increased Alzheimer’s risk

Question 10

HLA-DQ2 & HLA-DQ8

Answer 10

celiac disease risk

Question 11

APOA2

Answer 11

increased risk of obesity with high saturated fat diet above 22 g/day

Question 12

MTNR18

Answer 12

delay in melatonin getting turned off
delay in insulin getting turned on

since insulin isn’t present, high blood sugar

increased risk of T2D

Question 13

SNPs are really what

Answer 13

Enzymes

When we say we that we are up regulating a SNP, we are really saying that we are up-regulating that particular enzyme

Question 14

ACE alleles and what they do

Answer 14

GA/AA - unregulated enzyme; salt has impact on hypertension

GG - no change in enzyme; reduced salt will not have positive impact on blood pressure