Smooth Muscle Serotonin

Question 1

after synthesis of serotonin it is either stored or inactivated by _______________

Answer 1

monoamine oxidase

Question 2

in the pineal gland, serotonin is a precursor to ______________________

Answer 2

melatonin

Question 3

fx serotonin activity is linked to?

Answer 3

1. mood 2. sleep 3. appetite 4. temperature regulation 5. pain perception 6. regulation of BP 7. vomiting

Question 4

________________ has been linked to conditions like: depression, anxiety, and migraines

Answer 4

serotonin

Question 5

90% of serotonin in the body is found in ___________________ cells

Answer 5

enterochromaffin

Question 6

serotenergic neurons are typically located where?

Answer 6

1. raphe nuclei of brain stem 2. around blood vessels

Question 7

all serotonin receptors are ___________________ except the _______________ receptor

Answer 7

GPCR (metabotropic); 5-HT3

Question 8

5-HT3 nervous system effects

Answer 8

1. vomiting reflex 2. stimulator of pain and itching with plant and insect stings 3. Bezold Jarisch reflex (bradycardia and hypotension)

Question 9

serotonin effects on respiratory system

Answer 9

1. small direct stimulant effect on bronchial smooth muscle 2. faciliates Ach release from bronchial nerve endings 3. hyperventilation

Question 10

CV effects are stimulated by what serotonin receptor

Answer 10

5-HT2

Question 11

serotonin CV effects

Answer 11

1. vasoconstrictor in pulmonary and renal vessels 2. vasodilator in skM and heart 3. increases plt aggregation

Question 12

GI system effects of serotonin

Answer 12

1. stimulant of GI smooth muscle 2. increases tone 3. facilitates peristalsis (prokinetic)

Question 13

___________________ is an excess of serotonergic activity in the CNS

Answer 13

serotonin syndrome

Question 14

sx of serotonin syndrome

Answer 14

1. HTN 2. hyperreflexia, tremor, clonus 3. hyperthermia 4. hyperactive bowel sounds 5. diarrhea 6. mydriasis 7. agitation 8. coma

Question 15

tx of serotonin syndrome

Answer 15

1. 5-HT2 antagonist 2. Benzos and muscle relaxants (for hyperreflexia) 3. intubation and mechanical ventilation (for coma)

Question 16

medications that cause serotonin syndrome

Answer 16

1. SSRIs 2. 2nd generation anti-depressants (atypical) 3. MAOIs 4. linezolid 5. tramadol 6. meperidine 7. fentanyl 8. zofran 9. sumatriptan 10. mdma 11. LSD 12. St. johns wort 13. ginsent

Question 17

What medications are your serotonin RECEPTOR agonists

Answer 17

1. buspirone 2. dexfenfluramine 3. sumatriptan 4. cisapride 5. tegaserod 6. fluoxetine

Question 18

T/F: serotonin has no clinical application as a drug

Answer 18

true; but serotonin receptor agonism is clinically effective

Question 19

what drug is a serotonin receptor agonist that is highly toxic, and used only in palliative care

Answer 19

cisapride

Question 20

reserpine is what type of drug

Answer 20

serotonin antagonists

Question 21

MOA of resperine

Answer 21

NAME?

Question 22

________________ is a serotonin antagonist used in the tx of HTN

Answer 22

resperine

Question 23

adverse effects of resperine

Answer 23

1. sedation 2. fatigue 3. nightmares 4. depression 5. EPS 6. diarrhea and GI cramps

Question 24

what is the major therapeutic approach to conditions of serotonin excess?

Answer 24

serotonin receptor blockade

Question 25

what two meds are serotonin antagonists still in research?

Answer 25

1. p-chlorophenylanlanine 2. p-chloroamphetamine

Question 26

what are your serotonin receptor antagonist drugs?

Answer 26

1. phenoxybenzamine 2. ergot alkaloids 3. cryoheptadine 4. ondansetron 5. Trazadone (5-HT2 selective)

Question 27

__________________ is a neurotransmitter that acts a local hormone in the gut, found on plts and is component of clotting process

Answer 27

serotonin

Question 28

____________________ is found in plant & animal tissues, venoms, and stings

Answer 28

serotonin