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Pharmacology 2 > Smoking > Flashcards

Smoking Flashcards

1
Q

Type of receptor that nicotine acts on

A

Nicotinic ACh Receptor (Parasympathetic)

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2
Q

___ can be considered for pregnant women

A

Oral NRT

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3
Q

___ is responsible for the dependence and addiction with nicotine

A

Dopamine Levels

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4
Q

2 Most Effective Nicotine Interventions

A

Varenicline and Wellbutrin

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5
Q

Activity in the __ is directly responsible for initiating addictive effects of nicotine

A

VTA

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6
Q

Adverse effects with Mecamylamine

A

Drug-induced autonomic dysfunction or imbalance

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7
Q

Adverse events of Bupropion (Wellbutrin)

A

Insomnia, Dry Mouth, Nausea

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8
Q

All addictive drugs increase DA conc. in ___

A

Mesolimbic Projection

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9
Q

Both Varenicline and Wellbutrin are associated with

A

Psychiatric Adverse Effects

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10
Q

Bupropion (Wellbutrin SR)

A

NE and DA re-uptake inhibitor

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11
Q

Bupropion (Wellbutrin) vs Varenicine (Chantix)

A

Bupropion better than nicotine replacement but less effective than Varenicline

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12
Q

Clonidine (Catapres)

A

Oral Anti-hypertensive, blocks adverse effects of nicotine withdrawal

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13
Q

Mecamylamine (Inversine)

A

Nicotine Antagonist (Ganglionic Blocker)

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14
Q

Most common adverse effect of Varenicline (Chantix)

A

Self-limiting nausea

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15
Q

Most effective single drug for smoking cessation

A

Varenicline (Chantix)

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16
Q

Naltrexone (ReVia)

A

Opiate Antagonist; Found not effective for smoking cessation

17
Q

NE and DA re-uptake inhibitor

A

Bupropion (Wellbutrin SR)

18
Q

Nicotine Antagonist (Ganglionic Blocker)

A

Mecamylamine (Inversine)

19
Q

NRT that produces most constant nicotine blood level

A

Patch

20
Q

Opiate Antagonist; Found not effective for smoking cessation

A

Naltrexone (ReVia)

21
Q

Oral Anti-hypertensive, blocks adverse effects of nicotine withdrawal

A

Clonidine (Catapres)

22
Q

Partial agonist of a4b2 nACh receptor

A

Varenicline [Chantix]

23
Q

Structure of nACh receptor

A

Pentameric, Transmembrane

24
Q

The initial activation by nicotine of GABA neurons in VTA

A

produces rewarding effects thru GABA-dependent system that projects to TPP

25
Q

Varenicline [Chantix]

A

Partial agonist of a4b2 nACh receptor

26
Q

Why have ganglionic (nicotinic) blocking drugs fallen from favor

A

widespread actions they have both upon para and sympathetic nervous systems

Pharmacology 2 (8 decks)

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