Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmacology 2 > Alcohol > Flashcards

Alcohol Flashcards

1
Q

2 Enzymes involved in alcohol metabolism

A

Alcohol and Aldehyde Dehydrogenase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

2 Treatment options for Methanol/Ethylene Glycol intoxication

A

Fomepizole, Ethanol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

3 Drugs approved by FDA for Tx of Alcoholism

A

Disulfiram (Antabuse), Naltrexone (ReVia), Acamprosate (Campral)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

3 Treatments for Withdrawing Patient:

A

(1) Benzo: Diazepam; (2) Thiamine; (3) Electrolytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

4 Treatments for Intoxicated Patient:

A

(1) ABCs; (2) Dextrose; (3) Thiamine; (4) Electrolytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Acamprosate

A

Weak NMDA Antagonist, activator of GABAa receptors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Adverse effects of Acetaldehyde

A

Nausea, thus premise of Disulfram use in chronic alcoholics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Adverse effects of Ethylene Glycol

A

Acidosis, Nephrotoxicity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Adverse effects of Methanol

A

Acidosis, Retinal Damage

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Alcohol DH competitive inhibitor

A

Fomepizole

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Antidote to NAPQI (Acetominophen intermediate)

A

N-Acetylcysteine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Disulfiram

A

Inhibits Aldehyde Dehyrdrogenase; Encourages abstinence from alcohol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Disulfiram-like effects

A

Increase Acetylaldehyde levels

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Drug interaction for Ethanol in Diabetics

A

Increased risk of Hypoglycemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Ethanol is an important inducer of ___

A

CYP2E1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Fomepizole

A

Alcohol DH competitive inhibitor

17
Q

For both Ethylene Glycol and Methanol, the conversion to toxic products involves

A

Alcohol DH

18
Q

Highly reactive intermediate of Acetominophen

A

NAPQI

19
Q

Inhibition of what enzyme causes facial flushing after ethanol consumption

A

Aldehyde DH

20
Q

Inhibits Aldehyde Dehyrdrogenase; Encourages abstinence from alcohol

A

Disulfiram

21
Q

Interaction b/t Ethanol and NSAIDS/Anticoagulants

A

Increased risk of bleeding

22
Q

Metabolism of alcohol is ___ order metabolism

A

Zero

23
Q

mu opiate receptor antagonist; decreased reward

A

Naltrexone

24
Q

Naltrexone

A

mu opiate receptor antagonist; decreased reward

25
Q

There is very little involvement of ___ in the processing of alcohol

A

CYP metabolism

26
Q

Weak NMDA Antagonist, activator of GABAa receptors

A

Acamprosate

27
Q

Wernicke-Korsakoff Syndrome

A

Alcohol toxicity secondary to Thiamine Deficiency

28
Q

Why might Lorazepam be preferable to Diazepam in Withdrawing patient

A

Concerns over hepatic function

Pharmacology 2 (8 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions