Pharmacokinetics

Question 1

Limiting variable for clearance

Answer 1

Blood flow to the organ

Question 2

= (F x Dose) / (CL x T)

Answer 2

Css

Question 3

0.7/t^(1/2)

Answer 3

Half Life

Question 4

A drug is often given at __ intervals

Answer 4

half life intervals

Question 5

CL =

Answer 5

Rate of Elimination / Concentration

Question 6

Clearance is defined as

Answer 6

Volume of fluid from which a drug is removed per unit time

Question 7

Constant fraction of drug is eliminated per unit time

Answer 7

First Order Kinetics

Question 8

Css

Answer 8

= (F x Dose) / (CL x T)

Question 9

Css for Zero Order =

Answer 9

(Km x DR) / (Vm - DR)

Question 10

Dose =

Answer 10

(Css x CL x T) / F

Question 11

Dose Rate for Zero Order =

Answer 11

(Css x (Vm - DR)) / Km

Question 12

Dosing Rate =

Answer 12

CL x Css (Css=Steady State Conc.)

Question 13

Dosing Rate for maintenance doses =

Answer 13

Target Css x CL / F

Question 14

Drugs with short half lives are preferably given

Answer 14

IV

Question 15

Elimation rate constant (Ke)

Answer 15

Slope of time (linear) vs blood concentration (log)

Question 16

Extracellular Fluid Volume

Answer 16

12 L

Question 17

F x Dosing Rate =

Answer 17

CL x Css

Question 18

Fluid volume that would be required to contain all of the does at the same conc

Answer 18

Volume of Distribution

Question 19

Half life is time it takes for

Answer 19

plasma concentration to be reduced by 50%

Question 20

How many half lives to achieve steady state

Answer 20

about 5

Question 21

If enzyme that metabolize a drug is rate limiting

Answer 21

Zero Order Kinetics

Question 22

Influsion Rate / Total Body Clearance =

Answer 22

Css

Question 23

Ke =

Answer 23

CL / Vd or 0.7/t^(1/2)

Question 24

Km in zero order kinetics

Answer 24

Dose that produces 50% of maximal elimination rate

Question 25

Loading Dose

Answer 25

Desired steady state of a drug times the volume of distribution adjusted for bioavailability

Question 26

Loading Dose =

Answer 26

(Css x Vd) / F

Question 27

Most drugs obey ___ order kinetics

Answer 27

First Order Kinetics

Question 28

Most important concept to consider when given a long term drug

Answer 28

Clearance

Question 29

One compartment open model works for drugs that are

Answer 29

distributed fairly uniformly throughout body

Question 30

Plasma volume

Answer 30

4 L

Question 31

Slope of Time (linear) vs blood conc (log) is

Answer 31

Elimination Rate Constant (Ke)

Question 32

Time required to reach steady state for IV infusion is

Answer 32

5 half lives

Question 33

Time to steady state is __ of dose

Answer 33

Independent

Question 34

Time to steady state is __ of dose interval

Answer 34

independent

Question 35

Time to steady state is strictly dependent on

Answer 35

Half Life (Plateau principle)

Question 36

Total Body Water

Answer 36

40 L

Question 37

Two compartment model assumes

Answer 37

Much of the drug is in a particular compartment, and that equilibrium exists b/t blood and other areas

Question 38

Vm in zero order kinetics

Answer 38

Maximum rate of the process

Question 39

When a drug is cleared by a certain organ, __ is the limiting variable

Answer 39

blood flow to that organ

Question 40

When is loading dose warranted

Answer 40

when cannot wait 5 half lives to achieve therapeutic range

Question 41

With a multicompartment model, CL =

Answer 41

dose / AUC