Smartdeck Flashcards
would a disease of bone marrow suppression also show reticulocytes in the CBC?
no
reticulocytosis is uncommon because the bone marrow cannot efficiently generate cells
ESRD, hypercalcemia, hyperphosphatemia, hyperparathyroidism, obesity, diabetes, oral anticoagulants are all risk factors for
calciphylaxis (calcific uremic arteriolopathy)
systemic arteriolar calcification and soft-tissue calcium deposition with local ischemia and necrosis
Calcific uremic arteriolopathy
what electrolyte inhibits extraosseous calcification?
magnesium
HTN, epistaxis, and HA in younger patient
coarctation of the aorta
pt with hx of HA and htn then gets anesthesia and HTN escalates immediately
catecholamine surge from pheo
type of therapy with schizophrenic pt?
family therapy
What does the initial evaluation of HTN include?
serum chem panel, UA, Hgb/Hct, lipids and glucose
defective mineralization of the bone matrix
osteomalacia
osteomalacia is MC due to
severe Vit D deficiency
will calcium be increased or decreased in multiple myeloma?
increased
hypercalcemia
codfish vertebral bodies and pseudofractures
osteomalacia
<2 yo with palpable abdominal mass, systemic symptoms, raccoon eyes, and opsoclonus-myoclonus syndrome
neuroblastoma
workup of possible nonbloody infectious diarrhea etiology
ova and parasites
nonprogressive motor dysfunction, characterized by abnormal tone, movement, and development in infant
cerebral palsy
possibly the biggest risk factor for CP
prematurity
first sign of CP?
delayed gross motor milestones
distal and facial muscle weakness with delayed muscle relaxation, (delayed release of handgrip)
myotonic dystrophy
autosomal recessive disorder associated with delayed gross motor milestones, proximal muscle weakness and hypotonia
spinal muscular atrophy
tethering of the spinal cord leads to
LE muscle atrophy and weakness with poor or absent reflexes
neonate with temperature instability and poor feeding
neonatal sepsis
2 cancers that go with elevated AFP
yolk sac tumor
hepatocellular carcinoma
lesions of multiple myeloma
osteolytic lesions only
bladder distention and hydronephrosis with oligohydraminos in utero is likely due to
posterior urethral valves
with tracheoesophogeal fistula in a fetus, would you have oligohydraminos or polyhydraminos?
polyhydraminos
most significant sequelea of posterior urethral valves?
pulmonary hypoplasia
three clinical uses of misoprostol
maintain PDA
induce labor for abortion
ppx against NSAID induced ulcers
toxicity of PPIs
C diff
osteoporosis
increased risk of aspiration PNA
triple therapy of H. pylori
clarithromycin
amoxicillin/metronidazole
PPI
octreotide indication
tx bleeding varices
VIPoma
acromegaly
carcinoid
4 drugs that could tx gastroparesis
erythromycin
metoclompramide
donparidone?
sissopride?
pills that cause esophagitis
NSAIDs
KCl
bisphosphonates
tetracyclines
3 drugs that tx hepatic encephalopathy
lactulose
rifaximin
neomycin
2 drugs that could tx chemo induced N/V
odansetron
apprepitant
first line alternative from stimulants for ADHD tx
atomoxetine (SNRI)
AMS walking into ED with unsteady gait, might as well ppx with
thiamine
sound of an AV fistula
continuous bruit with palpable thrill
sound of arterial pseudoaneurysm formation
systolic bruit
disorder that has impaired conversion of glycogen to glucose
glucose-6-phosphatase deficiency
(Type I glycogen storage disease/Von Gierke)
How do pts present with Glucose 6 phosphatase deficiency present?
3-4 mo old
hypoglycemia/seizures
Lactic acidosis
hyperuricemia
hyperlipidemia
doll like face with rounded cheeks, thin extremities, short stature, and protuberant abdomen due to hepatosplenomegaly
dx?
glucose-6 phosphatase deficiency
hypertensive end organ findings, but no HTN
masked HTN
initial step in eval of masked HTN
ambulatory BP monitoring
abdominal pain, peripheral neuropathy, positive urobilinogen
acute intermittent porphyria
Acute intermittent porphyria is autosomal dominant disorder of heme synthesis pathway that results in
reduced activity of porphobilinogen deaminase, building up neurotoxins of heme pathway intermediates
(porphobilinogen and aminolevulinic acid)
confirm dx of acute intermittent porphyria with
urinary porphyrin level
JAK2 mutations are common in myeloproliferative disorders like
polycythemia vera
4 causes of hyperandrogenism in pregnancy
placental aromatase deficiency
luteoma
theca lutein cyst
sertoli-leydig tumor
differentiate luteomas of pregnancy and theca lutein cysts in prego
- luteomas of prego
- solid, unilateral or bilateral ovarian masses
- moderate virilization risk (high fetal risk)
- spontaneous regression of masses s/p delivery
- theca lutein cyst
- cystic, bilateral ovarian masses
- moderate virilization risk (low fetal risk)
- spontaneous regression of masses s/p delivery
rubella non-immune prego lady - next step
MMR immediately pp
when do you give Rhogam?
at 28 weeks and immediately after delivery if infant is Rh(D) +
differentiate SBO and ileus on XR
SBO has a discrete transition point (ie obstruction)
ileus has uniformly dilated bowel loops due to generalized bowel paralysis throughout
post op ileus tx
conservative tx - antiemetics, bowel rest, serial examinations
what kind of iron levels is thalassemia associated with?
normal or elevated iron and ferritin levels
histopath of intestinal lymphoma
diffuse infiltrate by atypical lymphocytes
chronic malabsorptive diarrhea, wt loss, migratory non-deforming arthritis, lymphadenopathy, and a low grade fever
whipple disease
what happens to the proximal clavicle when you have an abduction somatic dysfunction?
stays up, should move down when you shrug
what happens to the proximal clavicle in an adduction somatic dysfunction
stays down
(should move upward)
rapidly expanding breast mass
dx? tx?
phyllodes tumor
wide local excision
voiding cystourethrogram can be used to dx
diverticula, obstruction, reflux, stress incontinence, and in trauma to asess for bladder and urethral injury
5 drugs you can use as mood stabilizers for severe affective dysregulation in Personality disorders
carbamazepine
lithium
lamotrigine
topiramate
valproate
pure motor stroke is likely due to occlusion where?
lenticulostriate arteries
lacunar stroke
flushing, diarrhea, R sided heart issue
carcinoid syndrome
water hammer pulse
aortic regurg
murmur with inspiration
right side of heart issue
cirrhosis and pleural effusion
hepatic hydrothorax
how does hepatic hydrothorax occur?
small defects in the diaphragm
tx of hepatic hydrothorax
salt restriction and diuretics
recommendation when you have Hep C
vaccinate against Hep A and B
Lamivudine MOA and indication
reverse transcriptase inhibitor
tx HIV and chronic Hep B co infection
tx of akathisia
reduce antipsych drug and add beta blocker
4 AIDs defining malignancies
Kaposi sarcoma
Invasive cervical carcinoma
Non Hodgkin Lymphoma
Primary CNS lymphoma
methylmalonic acid in B12 and folate deficiencies
B12 deficiency has increased MMA
folate deficiency has normal MMA
gamma tetramers aka
Hgb Barts
alpha thalassemia
lab studies in alpha thalassemia
microcytic anemia
elevated RBC ct
target cells on peripheral smear
3 gene loss in alpha thalassemia?
hemoglobin H
cervical cancer presentations
intermenstrual or postcoital bleeding
exophytic friable growth, or painless, ulcerative lesion
reverse warfarin with
IV Vit K and prothrombin complex concentrate
antifibrinolytic agent that may be used to treat heavy menstrual bleeding and prevent excessive blood loss during certain types of surgery
tranexaminc acid
hormone levels in Turner syndrome
decreased estrogen
leading to elevated FSH and LH
vision loss and HA due to retinal and CNS hemangioblastomas along with family hx
Von Hippel Lindau
manifestations of von hippel lindau
hemangioblastomas
clear cell renal cell carcinoma
pancreatic neuroendocrine tumors
endolymphatic sac tumors of the middle ear
pheochromocytomas
surge of catecholamines
pheochromocytoma
associations with anterior uveitis
infections causing systemic inflammation
spondyloarthritis
IBD
younger person with painful, red eye, tearing, and decreased visual acuity
anterior uveitis
fever, AMS, petechial rash in younger person
starts to go shocky, hyponatremia and hyperkalemia
dx?
waterhouse friedrichsen
hemorrhagic necrosis of adrenal glands (T10)
posterior margin of TFL for counterstrain tenderpoint PL4 tx
hip extension, abduction, external rotation
innominate rotation occurs around what sacral axis?
inferior transverse axis
shifting weight side to side engages what sacral axes?
oblique axes
whichever way L5 is sidebent will be the side of?
the oblique axis?
inferior or inferolateral tip of spinous process C2 is what posterior tenderpoint and what is counterstrain tx?
PC3
Flex, sidebend away, rotate away
how much time do you need between stopping an MAO-I and an SSRI
2 weeks
pt with hemochromatosis is susceptible to what bugs?
vibrio vulnificus
listeria
yersinia
hyporeflexia, hypotension, respiratory depression, drowsiness, muscle weakness is all toxicity of
magnesium sulfate OD
magnesium sulfate antidote
calcium gluconate
prior to starting infliximab, check for
TB with PPD
toxicity of calcium carbonate
hypercalcemia, hypophosphatemia, milk alkali syndrome
AE of sulfasalazine
reversible oligospermia
hepatotoxic
stomatitis
H2 blockers that decrease renal excretion of creatinine
ranitidine
cimetidine
toxicity of cimetidine
anti andronergic
impotence, decreased libido
confusion, HA, dizziness
toxicity of bismuth
black tongue, teeth, and stool
quad therapy for H. pylori
bismuth, metronidazole, tetracycline, PPI
macrolides given in early infancy can increase risk of
pyloric stenosis
first line tx for allergic rhinitis
glucocorticoid nasal spray
infants become cyanotic during feeding or crying, or older children getting cyanosis on exertion or exercise
tet spell - tetrology of falot
labs in klinefelter syndrome
elevated gonadotroping hormone (LH and FSH)
decreased Testosterone
low testosterone with elevated LH and FSH indicates… and prompts…
primary hypogonadism
karyotype analysis
pharm tx for binge eating disorder?
SSRIs, stimulants (phentermine, lisdexamfetamine), and antiepileptics (topiramate, zonisamide)
increased body temp, elevated BP, increased RR, tachycardia, tremulousness, increased reflexes, sz, disorientation, AMS or frank delirium, and psychosis are all symptoms of
benzo withdrawal
extrahepatic manifestations of Hep C
heme: mixed cryoglobulinemia syndrome
Renal: membranoproliferative GNephritis
Derm: PCT, lichen planus
MCHC and MCV in spherocytosis
MCHC will be elevated
MCV will be low or normal
restlessness, fatigue, poor concentration, irritability, muscle tension and impaired sleep
along with concern over life issues for more than 6 months
generalized anxiety disorder
scaly papules or plaques on the scalp, face, lateral neck, and dorsum of hands
actinic keratosis
mono like syndrome, generalized macular rash, GI symptoms
acute HIV infxn
focal increase in bone turnover, in which osteoclast dysfunction leads to bone breakdown and compensatory increase bone formation
Paget disease
micro findings of increased number of abnormal appearing osteoclasts with disorganized, “mosaic” pattern of bone
Paget disease of bone
what happens to osteoblast activity in Pagets disease
increase activity
3 risk factors for osteonecrosis
glucocorticoid use
sickle cell disease
heavy alcohol use
dx thromboangiitis obliterans
with arteriogram after ruling out everything else including ANA and other abs titers
giant painful chalky nodules
tophi, gout
AE of venlafaxine
dose dependent HTN
2 least likely Second Gen Antipsychotics to cause weight gain
aripiprazole and ziprasidone
pharm vasodilator stress testing causes
marked increase in blood flow in nondamaged vessels and to a lesser extent, increased blood flow in stenosed vessels
definitive tx of chronic ITP
splenctomy
spiking fevers in the evening in a kid with joint pain
systemic juvenile idiopathic arthritis
lacy white network of lines in the mouth
lichen planus
(Wickham striae)
nerve that might be injured with brachial artery cannualization
median nerve
contraindications to IUD placement
pregnancy
endometrial or cervical cancer
unexplained vaginal bleeding
gestational trophoblastic disease
distorted endometrial cavity
acute pelvic infection
Contraindications to progestin IUD specifically
active liver disease
active breast cancer
MCC of congenital hypothyroidism
thyroid dysgenesis
core feature of atypical depression
mood reactivity - positive response to pleasant events
also, wt gain, hypersomnia, leaden paralysis, and hypersensitivity to objection
persistent depressive disorder/dysthymia time frame
chronically depressed mood for >2 years
definitive test for dx of carpal tunnel
nerve conduction studies
Pleural effusion tap shows milky white fluid with high triglycerides
chylothorax
young female, generalized weakness and lightheadedness, difficulty ambulating.
fatigue, nausea, abdominal pain, weight loss
primary adrenal insufficiency
hyperpigmented mucosa in young female
primary adrenal insufficiency
peripheral eosinophilia, no parasites
primary adrenal insufficiency
finger like projections on vocal cords
HPV
anterior mediastinal masses
thymoma, teratoma, thyroid neoplasm, terrible lymphoma
untreated hyperthyroidism can lead to
rapid bone loss
tachyarrhythmias
What does the left ventricle do in hypovolemic shock?
has decreased filling so increase HR and increase EF
exaggerated fall in systemic blood pressure, greater than 10 mmHg during inspiration
pulsus paradoxus
three conditions you might see pulsus paradoxus
cardiac tamponade
severe asthma
severe COPD
decompensated heart failure is a common cause of
secondary mitral regurg
lateral papillary muscle displacement because of dilation of mitral valve annulus
is stroke 2/2 endocarditis a contraindication to thrombolytic therapy?
yes
severe HTN with onset after age 55
renovascular disease
high plasma aldosterone to renin ratio >20:1
primary aldosteronism
dx of primary adrenal insufficiency is made by
cosyntropin stimulation test
result will have low production of cortisol
tx of sternal dehisence
emergent surgery and fixation
low levels of 5 -HIAA in CSF are associated with
suicidal behavior
direct factor Xa inhibitors like rivaroxaban and apixaban are contraindicated in
severely impaired renal dysfunction or in DVT/PE secondary to malignancy
first step in work up of elevated alk phos of unknown origin
check GGT
normal = likely bone origin
elevated = likely biliary origin
d-xylose test in a celiac + pt
positive test, increased d-xylose excreted in the urine
d-xylose test in chronic pancreatitis pt
negative test, increased excretion of d-xylose in urine
ultrasound findings in congenital toxoplasmosis
bilateral ventriculomegaly
diffuse intracranial calcifications
paraplegia with severe hypertension, HA, diaphoresis, flushing, and bradycardia in the setting of urinary retention
autonomic dysreflexia
potentially fatal complication of spinal cord injury
carotid sinus hypersensitivity typically causes
bradycardia, hypotension
severe hypospadias can be indicative of
disorder of sex development
microcephaly, wide anterior fontanelle, cleft lip and palate, and distral phalange hypoplasia
fetal hydantoin syndrome
what electrolyte imbalance can precipitate ogilvie syndrome?
hypokalemia, hypomagnesemia
spiral fx of the distal tibia in ambulatory children <3 are known as
toddlers fx
tx of toddlers fx
immobilization and pain control
MC congenital heart disease, Tetralogy of Fallot has what four features
VSD
overriding aorta (over R and L ventricles)
RVOT obstruction
RVH
Clinical features of Paget disease
- most asx
- Bone pain and deformity
- skull - HA, hearing loss
- spine - spinal stenosis, radiculopathy
- long bones - bowing, fx, arthritis of adjacent joints
- Giant cell tumor, osteosarcoma
isolated, asx, elevation of alk phos in elderly pt
paget disease of bone
large mediastinal mass, elevated LDH, and eosinophilia raise strong suspiscion for
hodgkin lymphoma
recurrent forceful contraction of the eyelid muscles
blepharospasm, a form of focal dystonia
why should you avoid antidepressant monotherapy in a bipolar pt
induce mania
first line tx of bipolar depression
second gen anti psychs - quetiapine and lurasidone
what sound can be heard in most patients during the acute phase of MI
abnormal S4, atrial gallop
MEN IIb
Medullary thyroid cancer
Pheo
Mucosal neuroma/marfanoid habitus
initial mgmt of ascites
sodium restriction, spironolactone and furosemide
most cases of ludwig angina are from
dental infections
tx of unstable angina or NSTEMI initially
antiplatelets and anticoagulant therapy
beta blockers
nitrates
statins
cardiac complication in a Turner pt
aortic dissection
genotypically male, phenotypically female
breast development, absent or minimal axillary and pubic hair, female external genitalia, absent uterus, cervix, and upper one third of vagina, cryptorchid testes
androgen insensitivity syndrome
refeeding syndrome is the result of
increased insulin activity
time frame of adujstment disorder
develops within 3 months of an identifiable stressor
the anemia of lymphoproliferative disorders, such as leukemia and lymphoma, is due to
the replacement of RBC progenitor cells with cancer cells in the bone marrow
(bone marrow infiltration)
first line treatment of alcohol use disorder
naltrexone (mu opioid receptor antagonist)
acamprosate (glutamate modulator)
first line antibiotics for asx bacturia in pregnancy
cephalexin, amoxicillin-clavulanate, or nitrofurantoin
an enlarged, uclerated tonsil with ipsilateral cervical adenopathy is likely..
oropharyngeal/head and neck squamous cell carcinoma
HPV
aquagenic pruritis, facial plethora, and dramatically elevated hematocrit
polycythemia vera
classic thrombotic complication from polycythemia vera
budd chiari syndrome