Small Molecules Flashcards
1
Q
4 Pros of small molecule drugs
A
Oral Bioavailability
Cheap
Stable
Can act intracellularly
2
Q
Two examples of small molecule drugs
A
HIV ART, Pipericillin, Aspirin
3
Q
Example drug of IC actions of small molecules
A
All three HIV ART drugs reverse transcriptase inhibitors etc
4
Q
3 cons of small molecule drugs
A
Lack of specificity
Resistance
Short Half life
5
Q
Example of small molecule short half lives
A
Aspirin needs to be taken every 4 hours
6
Q
Example drug of small molecule off target effects
A
Aspirin stopping global PG production
Piperacillin ruining microbiome
7
Q
Example of drug resistance to small molecule drugs
A
MRSA- mutated PBP2a so penicillin no longer binds to the DD transpeptidase
8
Q
example of small molecule affected by first pass metabolism
A
Atorvastatin
