Immunotherapy Flashcards
1
Q
5 pros of immunotherapy
A
Very effective
Very long duration of action
Fewer off target effects
Personalised
Enhance immune response
2
Q
5 cons of immunotherapy
A
Antigen escape- resistance
Off tumour effects
Struggles to infiltrate solid tumours
Immunosuppressive tumours
Toxic
3
Q
Example of effective immunotherapy
A
CAR-T cell for leukaemia- induced complete remission in 90% of patients
4
Q
Example of antigen escape in immunotherapy
A
CD19 down regulated by cancer cells
5
Q
Example of off tumour immunotherapy effects
A
Kills all B cells, not just cancerous ones
6
Q
Example of immunosuppressive tumour microenvironment
A
Poor T cell expansion, limited T cell life span
7
Q
Example of immunotherapy toxicity
A
Massive T cell expansion
Cytokine release
Hyperinflammation
