Antibiotic- Piperacillin Flashcards
Why are Abx important
- Saved thousands from dying from bacterial infections
- Revolutionised medicine
How many deaths a year do Abx save
1 million a year since 1990
what are the types bacteria Amoxicillin can treat
Gram +ve
Some Gram -ve
what diseases can Piperacillin treat
Meningitis
Diptheria
Tetanus
Scarlet Fever
How is Piperacillin Metabolised
- Absored through gut
- Excreted through urine unchanged
Is Piperacillin metabolised by P450
No significant P450 interaction
How to combat Abx resistance
- Full courses must be taken
- Only used for susceptible organisms
Which bacteria class can Piperacillin now treat
Enterococci
How does Piperacillin enter gram +ve bacteria
Through the cell wall
How does Piperacillin enter gram -ve bacteria
Through membrane porins
Why do bacteria have a peptidoglycan cell wall
- Encases plasma membrane
- Prevents osmotic lysis and gives structure
- Constantly remodelled during replication and growth
How does Piperacillin kill bacteria
inhibits cross linking of peptidoglycan within the cell wall
Which part of piperacillin is key for killing bacteria
Penicillin B lactam ring binds to DD-transpeptidase stopping cell wall remodelling
What does DD-transpeptidase do
catalyses remodelling of peptidoglycan cell wall
How does the weakened cell wall kill the cell
Osmotic pressure collapses the cell wall
How are the remaining cell wall fragments disposed of
fragments activate hydrolases which break down the wall
What can piperacillin be combined with to kill resistant bacteria
B lactase inhibitor
How have some bacteria become piperacillin resistant
Developed a B lactamase, stopping interaction with the DD transpeptidase
what class of drug is piperacillin
Small molecule penicillin derivative
