Small + large intestine conditions Flashcards
Name 2 malabsorption disorders of the SI
Coeliac disease
Crohn’s (doesn’t just affect SI)
Define maldigestion v malabsorption
Maldigestion = Impaired breakdown of food in the intestinal lumen, e.g. lack of pancreatic enzymes, following gastric resection, bile acid deficiency
Malabsorption = Impaired absorption of digested food caused by alterations of the intestinal mucosa
Are Crohn’s disease and coeliac disease malabsorptive or maldigestive disorders
Malabsorptive
General symptoms (3) /signs (5) of malabsorption
Increased appetite
Bloating
Fatigue
Weight loss Diarrhoea Steatorrhoea (fat malabsorption --> fatty stool) Clubbing Apthous ulcers (crohn's)
Signs of iron deficiency (4)
Anaemia:
- Fatigue
- Pale skin
- Dyspnoea on exertion
- Koilonychia
Sign of vitamin A deficiency
Night vision impaired
Sign of vitamin K deficiency
Raised prothrombin time
Signs of vitamin
-B1
-B3
deficiency
Vitamin B1 (thiamine) deficiency –> memory loss
Vitamin B3 (niacin) deficiency –> dermatitis
Sign of vitamin C deficiency
Scurvy
Investigations of small intestine disorders (6)
Endoscopy + biopsy Barium follow through Enteroscopy - longer version of endoscopy CT MRI enterography Capsule enterography - pillcam
Investigations of bacterial overgrowth in SI (2)
H2 BREATH TEST (diagnostic of SI bacterial overgrowth and carbohydrate malabsorption)
Endoscopy + aspiration of duodenal/jejunal fluid –> then culture
What is coeliac disease
Autoimmune disease triggered by gluten (specifically gliadin component of gluten)
Sensitivity to gluten
Pathophysiology of coeliac disease
Immune activation –> inflammatory response to gliadin –> body produces anti-tissue transglutaminase) antibodies attacking the enzyme, tissue transglutaminase (tTG)), –> villous atrophy, hypertrophy of crypts and increased lymphocytes
Risk factors of coeliac disease (3)
Family history of coeliac
PMH or FH of autoimmune diseases - type 1 DM, thyroid disease
IgA deficiency
Symptoms (4) /signs (5) of coeliac disease
abdo pain
DIARRHOEA - most common
bloating,
fatigue
Steatorrhoea Weight loss Dermatitis herpetiformis (IgA deposit on skin) IgA deficiency Anaemia
Investigations of coeliac disease (4)
- serology (3)
- gold standard
Serology (test for antibodies): -Total IgA - for IgA deficiency -IgA-tTG antibody -anti-endomysial IgA (Some coeliacs are IgA deficient so ALWAYS measure total IgA)
Distal duodenal biopsy – GOLD STANDARD
Treatment of coeliac disease (2)
Gluten free diet
Nutritional support - calcium, vitamin D supplements
What is the characteristic histological finding of coeliac disease
+ other histological findings (3)
Villous atrophy
intraepithelial lymphocytes,
mucosal atrophy
crypt hyperplasia
What is the diagnostic investigation of coeliac disease
Distal duodenal biopsy
Other causes of small intestine malabsorption (4)
Infection, e.g. tropical sprue, HIV, giardiasis
Whipple’s disease
Iatrogenic - e.g. following gastric resection
Pancreas insufficiency
Treatment of small intestine bacterial overgrowth (3)
2 weeks each of:
Metronidazole
Tetracycline
Amoxycillin
What is IBD
A collective name for chronic inflammatory conditions of the bowel
Results from inappropriate and persistent activation of the mucosal immune system
Name the 3 types of IBDs
Crohn’s disease
Indeterminate colitis
Ulcerative colitis
Pathophysiology of IBD
Unknown activation of the immune system –> immune response against normal flora of the colon
Cause of IBD
Idiopathic
Thought to be due to combo of:
- Environmental triggers
- Immune dysfunction - possibly autoimmune
- Genetic predisposition
What is ulcerative colitis + is it superficial/deep + where does the inflammation begin (3)
CONTINUOUS inflammation of the colon
Inflammation is SUPERFICIAL – limited to mucosa
Inflammation always starts from the rectum and moves proximally
Risk factors of UC (3)
Family history of UC
HLA-B27 gene
Infection
Symptoms (2) /signs (4) of UC
Abdo pain (LLQ) Diarrhoea
Abdo tenderness
Rectal bleeding
Blood in stool
Malnutrition –> vit deficiencies, inable to maintain ideal weight
Symptoms/signs of a flare up/relapse of UC (worsened or additional symptoms to usual) (4)
Arthritis
Mouth ulcers
Irritated red eyes
Painful red swollen skin
Signs (4) of a severe UC attack
Stool frequency >6 a day with blood
Fever
Tachycardia
Dyspnoea
Investigations of UC (6)
- biochem
- imaging (2)
Stool test - elevated calprotectin
FBC - high WBC, high platelets
ESR - elevated
CRP - elevated
Flexible sigmoidoscopy
Colonoscopy + biopsy - DEFINITIVE
Treatment of UC (4 medical, 2 surgical)
Medication:
- 5ASA (aminosalicylates) - e.g. mesalazine, sulfasalazine
- immunosuppressants
- —–> steroids (prednisolone)
- —–> azathioprine*
- biologics (anti-TNFa antibodies - infliximab)**
Surgery
- proctocolectomy (rectum + colon removal) + permanent ileostomy (stoma) - most standard
- total colectomy + ileorectal anastomosis
*only used in refractory disease = if not responsive to normal treatment, i.e. 5ASA and steroids
**only used in refractory or severe disease
Pathological findings (i.e. if you were to look at it specimen physically) of UC (3)
Continuous pattern of inflammation
Inflamed RED granular mucosa
Pseudopolyps - projecting masses of scar tissue that have healed from ulceration (so old ulcer remnants)
Histological findings of UC (6)
Inflammatory infiltrates - high neutrophils
Mainly mucosal inflammation/ulcers + mucosal atrophy
CRYPT ABSCESSES/CRYPTITIS
NO GRANULOMAS
May get atypia (abnormal structure) of cells –> adenomatous change –> invasive cancer
Pathological findings (i.e. if you were to look at it physically) of Crohn’s disease (4)
GRANULAR serosa/dull grey
Mesentery - thickened and fibrotic
THICK COLON WALL –> NARROW lumen
‘Skip/cobblestone lesions’ - bits of normal colon then abnormal colon
Histological findings of Crohn’s (6)
NON-CASEATING GRANULOMAS
Cryptitis/ distortion of crypt cells
DEEP ulceration - TRANSMURAL inflammation
Fistula/stricture formation –> narrowing intestine
Fissuring ulcers
Lymphoid aggregates and neutrophil infiltrates
Is ulceration superficial/deep in UC vs crohn’s
UC - superficial
Crohn’s - deep
What is crohn’s disease
Disorder of unknown aetiology characterised by transmural inflammation (=all layers of bowel wall) of ANYWHERE in the GI) tract - from mouth to peri-anal area