GI immunology

Question 1

What do antigen presenting cells do (2) + examples (2)

Answer 1

Present foreign antigens to T cells in lymph nodes
Can secrete cytokines to tell cells around them to act upon the foreign antigen

Dendritic cells
Macrophages

Question 2

Examples of soluble mediators of immunity (2)

Answer 2

Chemokines

Cytokines

Question 3

Cells involved with innate immune response (6)

Answer 3

Granulocytes - neutrophil, eosinophil
Mast cell
Monocyte
Dendritic cell
Macrophage
Natural killer cell

Question 4

Cells involved with adaptive immune response (4)

Answer 4

T lymphocytes - CD4, CD8
B lymphocytes
Memory lymphocytes
Plasma cell

Question 5

What do soluble mediators do (cytokines/chemokines)

Answer 5

Cytokines determine what T cells differentiate into, e.g. Th1 or Th2 or Treg
They are released by cells and act upon cells

Question 6

What are peyer’s patches and where are they found

Answer 6

They’re lymphocyte aggregations that monitor intestinal bacteria and prevent growth of pathogens
Found in ileum

Question 7

Gut immune homeostasis is a balance between what 2 types of T cells

Answer 7

T helper and T regulatory cells