small intestine and appendix Flashcards
the duodenum
- extends from pylorus to ligament of treitz
- retroperitoneal
- 4 segments: duodenal bulb and descending duodenum which house major/minor duodenal papillae
minor and major papilla
minor- drainage of dorsal pancreatic duct (accessory duct of Santorini)
major- drains common bile duct and main pancreatic duct (duct of wirsung)
jejunum
more prominent plica circualres and longer vasa recta than ileum
blood supply of small intestine
primarily the superior mesenteric artery (SMA)
duodenum also supplied by gastroduodenal artery, originating from celiac axis via common hepatic artery
venous drainage of small intestine
superior mesenteric vein (SMV) which is joined by splenic and inferior mesenteric veins to constitute the portal vein
lymphatic drainage of small intestine
lacteals and lymphatic channels paralleling the venous drainage, joining at the cisterna chyli in upper abd below the aortic hiatus of the diaphragm
lymphatic tissue of terminal ileum
known as Peyer’s patches and terminates at ileocecal valve
nerve supply of small intestine and appendix
autonomic nervous system
parasympathetic fibers from vagus nerve and traverse to gut via celiac plexus
sympathetic fibers travel via splanchnic nerves from ganglion cells in superior mesenteric plexus
intestinal distention- sympathetic visceral afferent fibers
appendix
arises from the cecum at the confluence of the taenia coli and accompanied by an adjacent mesentery (mesoappendix) which courses the appendiceal artery as a terminal branch of ileocolic artery
how is the primary function of digestion and absorption of the small intestine accomplished
intestinal motility, activity of digestive enzymes, secretion of digestive juices, and absorptive processes predicted on both simple diffusion and active transport
autonomic and endocrine regulation
4 phases of migrating motor complex (MMC)
- quiescent w no spikes or contractions
- accelerating and intermittent spike and contractile activity
- sequence of high amplitude spiking activity and corresponding strong, rhythmic gut contractions
- brief migrate down the small intestine
total duration of cycle is 90-120m
where is vit b12, a, d,e,k and bile salts, calcium and iron absorbed
b12,a,d,e,k,bile salts- terminal ileum
ca/fe- duodenum and proximal small bowel
what does IgA for the gut immune system
suppress bacterial growth and adherence to epithelial cells
neutralizes bacterial toxins and viruses
what happens with SBO
lumen of the small intestine is blocked causing small bowel effluent to back up resulting in abd distension, n, v
mesentery can be compromised causing strangulation of the intestine w resulting ischemia and potentially bowel necrosis
closed loop bowel obstruction
complete obstruction where a portion of small intestine is obstructed both proximally and distally
high risk for strangulation and requires immediate surgery
intraluminal causes of SBO
foreign bodies, barium inspissation (colon), bezoar, inspissated feces, gallstone, meconium (cystic fibrosis), parasites, intussusception, polypoid
intramural causes of SBO
congenital (atresia, stricture, stenosis, web, meckels diverticulum)
inflammatory process (crohns, diverticulitis, ischemia, radiation enteritis, medication induced)
neoplasms (primary bowel, seconday)
trauma
extrinsic causes of SBO
adhesions, congenital (ladd/meckels bands, postop, postinflammatory)
hernias (ext/int)
volvulus
external mass effect (abscess*, annular pancreas, carcinomatosis, endometriosis, pregnancy, pancreatic pseudocyst)
MC SBO cause in industrialized and nonindustrialized
indust- postsurgical adhesions or scar tissue
nonind- inguinal or umbilical hernia
SBO due to internal hernias after laparoscopic gastric bypass
small mesenteric defects can be created through which small bowel can herniate and cause obstruction and potentially strangulation
metastatic peritoneal cancer as cause of extrinsic SBO
metastatic peritoneal implants, commonly from ovarian or colon cancer, may compress the small bowel lumen causing an intestinal obstruction
how do instrinsic causes affect the small bowel
causes thickening of the bowel wall and causes lumen to compromise forming a stricture within the small intestine not allowing solids to pass through the narrow lumen causing abdominal crampy pain
MC cause for benign stricture
Crohn’s disease
less common- radiation enteritis, ulcers from nsaids, previous small bowel resection
is strangulation assoc w bowel obstructions caused by strictures
not likely since mesentery is not compromised
how a foreign body (intraluminal cause) causes SBO
in some the ileocecal valve produces a slight narrowing that may form a barrier for some larger foreign bodies so they become impacted at the valve and an obstruction develops
what is the most serious complication of SBO
strangulation of the involved intestine because the bowel becomes ischemic and eventually infarcts as edema and kinking of the mesentery impact mesenteric vascular patency
indicators of a higher risk of strangulation
fever
tachycardia
leukocytosis
localized abd tenderness
pt w intermittent, intense, colicky pain relieved by vomiting of the epigastric region
proximal sbo (open loop)
pt with intermittent to constant pain that is diffuse and progressive, moderate abd distention, obstipation, and mild vomiting
distal sbo (open loop)
pt with progressive diffuse pain that was intermittent but rapidly worsened and is now constant, no abd distention
sbo closed loop
pt w continuous diffuse pain, w intermittent vomiting, marked abd distention and obstipation
colon and rectum obstruction
what should you be concerned about if pain and tenderness begin to localize in a more somatic pattern
bowel ischemia and peritonitis w attendant parietal peritoneal irritation
in an obese pt what may be the only clue to bowel incarceration within an otherwise occult hernia
areas of focal contour change, erythema or tenderness near a surgical scar
when will diffuse mild tenderness improve usually w sbo
after acute decompression via a nasogastric tube
initial imaging studies for sbo
abd series- supine and upright abd films
upright chest radiograph
imaging findings for sbo
bowel distention proximal to point of obstruction and collapse of bowel distal to same point
what do air fluid levels on an upright film indicate
lack of normal propulsive activity in affected loops of intestine
what represents closed loop obstruction on abd series
focal loops of intestine that are persistently abnormal
if the bowel is massively distended with air and it is difficult to distinguish the small and large bowel what should be done
water soluble contrast enema to exclude the possibility of a large bowel obstruction mechanism
when are contrast studies of the small intestine useful
pt w persistent partial obstructive symptoms or when it is difficult to distinguish paralytic ileus from mechanical obstruction
lab tests for sbo
helpful in excluding other causes
leukocytosis- if persists despite ng decompression and fluid resuscitation can mean progression toward ischemia
electrolytes closely monitored
hypokalemic- contraction of alkalosis w adv dehydration
hyperamylasemia- sbo but w marked degree heighten suspicion for acute pancreatitis
UA- excluding evidence for infection or stone
lactic acidosis- bowel ischemia
what is the most frequent ddx considered in setting of possible sbo
paralytic ileus
process of paralytic ileus
bowel motility is suppressed as a consequence of systemic or inflammatory illness and bowel may become distended and pt obstipated ; no mechanical obstruction
pt with minimal abd pain, n/v, obstipation, cant pass gas, abd distention, dec/absent bowel sounds, gas in small intestine and colon on xray
paralytic ileus
pt with crampy abd pain, n/v, obstipation, abd distention, norm/inc bowel sounds, gas in small intestine on xray
sbo
cause of POI
stress of surgery, fluid and electrolyte imbalances, pain management with narcotics
fast tract protocol
used to try and minimize POI by avoiding ng tubes, early ambulation, avoidance of fluid overload and early intro of diet
medication approved to dec length of POI
alvimopan- opioid antagonist that specifically targets the mu receptor responsible for the gi side effects of opioids
doesnt cross bbb so selectively blocks the peripheral receptors contributing to POI wout sig altering central analgesic effects of opioids
what does tx for sbo begin with
resuscitation, correction of fluid and electrolyte deficits
what is the best tool for assessing adequacy of volume replacement
foley catheter to assess urine output
at least 0.5mL/kg
what does an ng tube placement do
control emesis, relieve intestinal distention proximal to obstruction, lower risk of aspiration, allow monitoring of ongoing fluid and electrolyte losses
reduction en mass
hernia sac is reduced w the contents as a unit and therefore the contents may remain compromised despite being internalized
if there is question in regard to bowel viability what is an intraoperative assessment that is done
intraop assessment w fluorescein dye or doppler us to asses perfusion along with clinical evaluations of bowel viability such as color, bleeding, and peristalsis
what should be done if intussusception if found in adults
resection because of high likelihood of a lead point lesion
what are some complications that may complicate operative intervention for sbo
wound infection, anastomotic leak, abscess, peritonitis, and fistula formation
features of crohns ds
involves segments of GI tract other than the colon
sparing or skip lesions between affected areas
transmural involvement and assoc tendency to dev fistulas
noncaseating granulomata on histology
gradual onset with progression of abd pain, diarrhea, and weight loss
crohns
as progresses have malaise, fatigue, fever, weight loss, anorexia, n/v
dx crohns
colonoscopy w visualization of terminal ileum or barium enema w inspection of terminal ileum and small bowel contrast studies
biologies for crohns
infliximab
adalimumab
certolizumab
indications for surgery w crohns disease
perforation
fibrotic stricture- acute complete or chronic partial BO
fistula
what if a pt w a fistula fails to respond to medical management
resection of the communicating bowel and simple debridement or limited excision of the communicating cutaneous or nonenteric visceral tract
how long does the small intestine have to be maintained in order for them to sustain oral intake
100cm
complications of crohns
malnutrition, obstruction, fistulous ds, electrolyte distrubances
medication se
progression of ds resistant to medical therapy
wound infx, short bowel syndrome, wound healing problems, fistulae
anal incontinence
4 major etiologies for acute mesenteric ischemia (AMI)
sma embolism
sma thrombosis
mv thrombosis
nonocclusive mesenteric ischemia
SMA embolism
- originate from heart and assoc w afib
- thrombus forms win the heart and becomes dislodged, the clot passes downt he sma and lodges as the vessel narrows just distal to the take off of the middle colic artery completely occluding downstream flow
sma thrombosis
- freq assoc w vascular ds like CAD,PVD, chronic renal insuff
- chronic stenosis of the sma and if the vessel forms an acute thrombosis, ami may occur
- usually begins at origin of SMA and more likely to lead to complete SB infarction
smv thrombosis
- result of hypercoag state
- clot forms in smv obstructing venous outflow which results in venous htn, inc bowel wall edema and dec arterial flow
nonocclusive mesenteric ischemia (NOMI)
- usually dx in ICu setting in critically ill pts
- hx of toehr sig atherosclerotic ds
- in severe shock, blood shunted away from GI tract and if process cont there can be sig vasospasm of the splanchnic circulation, resulting in ischemia of sm/lg intestine
pt presents w severe rapid onset of pain, abd exam unimpressive
AMI
pain out of proportion to PE
presentation of SMV thrombosis and NOMI
smv- insidious onset, pain for several days or weeks, diffuse and nonspecific
nomi- min abd pain that is overshadowed,**hemodynamic instability (primary cause)
dx mesenteric ischemia
direct visualization of vascular tree via mesenteric arteriogram
delayed films to obtain a venous phase to determine if smv is thrombosed
CT is replacing
initial tx for mesenteric ischemia
rapid resuscitation and correction of any metabolic abnorm
abx
rapidly restore blood flow to gut, resect necrotic bowel and min reperfusion injury
tx for pt w sma embolism
immediate embolectomy via laparotomy
sma isolated and arteriotomy is performed
catheter placed directly into artery above clot and balloon inflated and catheter removed along with clot
tx for sma thrombosis
revasc required since sma chronically narrowed by severe atherosclerotic ds
sma bypass procedure or sma endovasc stent