colon, rectum, anus Flashcards
parts of the large intestine
- cecum is largest part and where small bowel joins colon (no distinct division between cecum and ascending colon which is retroperitoneal)
- hepatic flexure (inf to liver) bend in asc colon where it becomes transverse colon
- transverse colon suspends freely in peritoneal cavity by transverse mesocolon
- splenic flexure is where transverse colon bends at the spleen and is retroperitoneal
- descending colon is retorter down to sigmoid colon which is loop of redundant colon in llq
- distal colon is intraperi becomes the rectum at the sacrum then cont. to anal sphincters that form short (3cm) anal canal
rectum anatomy
- 15cm long
- teniae coli disperse and disappear at level of sacral promontory resulting in longitudinal muscle layer that becomes continuous homogeneous layer
- prox rectum covered by peritoneum ant not post to 10cm above anal verge
importance of knowing what part of the rectum is intraperitoneal
full thickness rectal bx taken from higher than 8-9cm above anal verge carries risk of free perf into peritoneal cavity
where does the anal canal extend from
anorectal junction (dentate/pectinate line) to anal verge
what does the dentate one mark
junction between columnar rectal epithelium (insensate) and the squamous anal epithelium (richly innervated by somatic sensory nerves)
columns of Morgagni (rectal columns)
- immediately proximal to dentate line
- where perianal glands discharge secretions, level of anal crypts
where do perirectal abscesses usually originate
columns of morgagni (anal crypts)
what is the blood supply of ascending colon and prox half of transverse colon
branches of sma
what is the blood supply of distal half of transverse colon, descending colon, and sigmoid colon
infer mesenteric artery
importance of understanding arterial blood supply in certain areas of colon
-junction of two separate blood vessel systems, blood supply is poor so anastomoses in this region would carry higher risk of ischemic complications
marginal artery of drummond
vessel runs parallel to about 2-3cm from descending colon wall and is a collateral that connects the middle colic and left colic systems
-provides adequate blood supply to descending colon even if left colic artery has to be sacrificed during sigmoid or distal descending colon surgery
venous drainage of large bowel
- most branches accompany the arteries and eventually drain into portal system
- inf mesenteric vein drains into splenic vein which joins w super mesenteric vein to form portal vein
arterial supply of rectum
branch of inf mesenteric artery (sup hemorrhoidal artery) for upper rectum and from branches of internal iliac arteries (middle hemorrhoidal arteries) and internal pudendal arteries (inf hem arteries) for the middle and lower rectum
venous supply of rectum
veins from upper rectum drain into portal system through inf mes vein; middle and inf rectal veins drain into systemic circulation through the internal iliac and pudendal veings
what are hemorrhoids
physiologic venous cushions that connect the two systems
lymphatic drainage of large intestine
parallels arterial blood supply w several levels of lymph nodes between periaortic plexus and parabolic lymph nodes
order of tumor metastases of lymph nodes
paracolic lymph nodes then middle tier of lymph nodes then periaortic lymph nodes
layers of bowel wall of colon
mucosa, submucosa, muscularis and serosa
what is the major histologic difference between colon and small intestine
- colon has no villi
- outer longitudinal smooth muscle layer is separated into 3 bands (teniae coli) that cause out pouching of bowel between teniae (haustra)
internal sphincter
continuation of the circular muscular layer of the rectum; invol sphincter made of smooth muscle
external sphincter
- striated voluntary muscle
- 3 parts: subq, superficial and deep portions
- deep portion is continuity w legator ani muscles (base of pelvic floor)
most important control of colon activity
mediated by regional reflex activity that occurs in submucosal plexuses
3 ways colon and rectum play role in maintaining hemeostasis
- absorb water and electrolytes from liquid stool
- through fermentation, help digest some starches and protein that are resistant to digestion and absorption by small bowel
- serve as storage for feces
mc anaerobic colonic organism
bacteroides fragilis
mc aerobic colonic organisms
e coli and enterococci
function of colonic bacteria
- degradation of bile pigments
- production of vitamin k
- fermentation of undigested starches and proteins
- produce short chain fatty acids that are absorbed by the colon
does a resection of entire colon and rectum impact a person’s capacity to maintain normal nutrition
no
what many L of chyme does the small bowel deliver to the cecum each day
1-2L
most is absorbed in ascending and transverse colon leaving
what does the colon absorb and secret
absorbs sodium and chloride
secretes bicarb and potassium
what regulates the final evacuation of solid stool
anorectum
how many ml/day of colonic gas does bacterial fermentation produce
800-900mL/day
what gives colonic gas its odor
indole and skatole
dx evaluation of colon and rectum
- DRE
- rigid sigmoidoscopy which been replaced by fiberoptic flexible sigmoidoscopy
- fiberoptic colonoscopy (most accurate)
- abd series (flat plate and upright radiograph)
- barium enema
- virtual colonoscopy or ct colography
- technetium labeled rbi scanning
- angiography
what should a sigmoidoscopy be performed
pts >50yr and performed every 3-5yrs
double contrast barium enema
using air insufflation while some intraluminal barium remains in the colon is particularly sensitive in detecting polyps and small lesions
what is a barium enema helpful in dx
tumors
diverticulosis
volvulus
obstruction
what is technetium labeled rbc scanning used
eval of lower gi bleeding (less rapid and pt stable)
what is angiography useful for
moderate or rapid colonic bleeding
what is a colostomy
surgical procedure in which the colon is divided and the proximal end is brought through a surgically created defect in abd wall and distal end is either overseen and placed in peritoneal vanity as a blind limb (Hartmann’s procedure) or brought out inferiorly to colostomy through abd wall as mucous fistula
what is the purpose of a colostomy
divert stool from a diseased segment distally in the colon or rectum or to protect a distal anastomosis
how is a loop colostomy created
bringing a loop of colon through a defect in abd wall, placing a rod underneath, and making a small hole in the loop to allow stool to exit into colostomy bag
what is an ileostomy
similar to colostomy in which the ileum is brought through the abd wall to divert its contents from distal ds or in proctocolectomy, to serve as permanent stoma
why are stomas created
(1) to allow healing from a distal anastomosis before bowel continuity is restored; (2) the ends of the bowel are not suitable for an immediate anastomosis after resection (e.g., severely inflamed bowel, questionable vascular supply); (3) when the conditions are not right for proceeding (e.g., severe fecal peritonitis, patient too unstable or too sick to tolerate the procedure); and (4) when there is not enough bowel left for reanastomosis (abdominoperineal resection [APR]).
proctocolectomy
operative removal of entire colon and rectum (ulcerative colitis or polyposis syndromes)
abdominoperineal resection
surgical tx of very low rectal cancers; removal of lower sigmoid colon and entire rectum and anus leaving a permanent proximal sigmoid colostomy
low anterior resection
tx cancers of middle and upper sections of rectum; removal of distal sigmoid colon and apporx one half of rectum w primary anastomosis of prox sigmoid to distal rectum
what are the white lines of toldt
lateral peritoneal reflections of the ascending and descending colon
what parts of gi tract do not have serosa
esophagus, middle and distal rectum
major differences between colon and small bowel
colon has taeniae coli, haustra, and appendices epiploicae (fat appendages) whereas the small intestine is smooth
blood supply of proximal rectum and venous drainage
superior hemorrhoidal (superior rectal) from IMA
imv to splenic vein then to portal vein
blood supply of middle rectum
middle hemorrhoidal (midde rectal) from hypogastric (internal iliac)
iliac vein to ivc
blood supply of distal rectum
inf hemorrhoidal (inf rectal) from pudendal artery (branch of hypogastric artery)
iliac vein to ivc
what is the mc gi cancer
colorectal carcinoma
risk factors for colorectal carcinoma
diet- low fiber, high fat
genetic- famhx, FAP, lynch syndrome
IBD- UC > crohns, age, prev colon cancer
what is lynch’s syndrome
HNPCC= Hereditary NonPolyposis Colon Cancer
autosomal dominant inheritance of high risk for dev of colon cancer
ACS recommendations for polyp/colorectal screening in asymp pts without 1st degree fam hx of colorectal cancer
starting age 50:
- colonoscopy q 10yrs
- double contrast barium enema (DCBE) q 5yrs
- flex sigmoidoscopy q 5yrs
- Ct colonography q5yrs
ACS recommendations for polyp/colorectal screening in asymp pts with 1st degree fam hx of colorectal cancer
colonoscopy at age 40 or 10 years before age at dx of youngest 1st deg relative and every 5 yrs thereafter
s/sx assoc w right sided lesions
r side of bowel has lg luminal diameter so tumor may attain a lg size before causing problems
microcytic anemia, occult/melena more than hematochezia PR, postprandial discomfort, fatigue
s/sx assoc w left sided lesions
left side fo bowel small lumen and semisolid contents
change in bowel habits (small caliber stools), colicky pain, signs of obstruction, abd mass, +heme, or gross red blood
n,v,constipation
from which site is melena more common
right sided colon cancer
which site is hematochezia more common
left sided colon cancer
s/sx of rectal cancer
mc is hematochezia or mucus
tenesmus, feeling of incomplete evacuation of stool, rectal mass
dx tests for colorectal cancer
hx/pe heme occult cbc barium enema colonoscopy
what ds does microcytic anemia signify until proven otherwise in man or postmenopausal woman
colon cancer
preop w/u for colorectal cancer
hx pe lfts cea cbc chem 10 pt/ptt type/cross 2u prbcs cxr ua abdominopelvic ct
means by which cancer spreads
direct extension-circumferentially and through bowel wall to later invade other abdominoperineal organs
hematogenous- portal circulation to liver; lumbar/vertebral veins to lungs
lymphogenous-regional lymph nodes
transperitoneal
intraluminal
what unique dx test is helpful in pts w rectal cancer
endorectal US
tnm stages
stage1- invades submucosa or muscularis propria (T1-2 N0 M0)
stage2- invades through muscularis propria or surrounding structures but w negative nodes (t3-4, N0, M0)
stage3- positive nodes, no distant metastasis (any T, N1-3, M0)
stage4- positive distant metastasis (any T, any N, M1)
preop bowel prep
- golytely colonic lavage or fleets phospho-soda until clear effluent per rectum
- PO abx (1g neomycin and 1g erythromycin x3doses)
pt should also receive preop and 24hr IV abx
common preop IV abx
cefoxitin (mefoxin), carbapenem
if alx- IV cipro and flagyl (metronidazole)
what determines low ant resection (LAR) vs abd perineal resection (APR)
distance from anal verge, pelvis size
what do all rectal cancer operations include
total mesorectal excision- remove rectal mesentery, including lymph nodes
what surgical margins are needed for colon cancer
traditionally >5cm; margins must be at least 2cm
how many lymph nodes should be resected w colon cancer mass
12min= for stage and may improve prognosis
adjuvant tx stage 3 colon cancer
5fu and leucovorin chemo
adjuvant tx for t3-4 rectal cancer
preop radiation therapy and 5fu chemo
mc site distant metastasis from colorectal cancer
liver
surveillance regimen of colorectal cancer
pe stool guaiac cbc cea lfts- every 3m for 3y then every 6m for 2y cxr every 6m for 2yr then yearly colonoscopy at yrs 1 and 3 postop ct scans directed by exam
mc causes of colonic obstruction in adult population
colon cancer
diverticular ds
colonic volvulus
what are colonic and rectal polps
tissue growth into bowel lumen usually consisting of mucosa, submucosa or both