shock Flashcards
shock
condition in which the total body cellular metabolism is malfunctional
what happens if shock goes untx
cellular death, organ damage, and eventual death of person
Tissue injury and the associated inflammatory response result in the production or activation of cellular molecules (i.e., cytokines, superoxide radicals, prostaglandins, adhesion molecules) that promote local cellular activation, tissue repair, and host defenses. However, sometimes this local response incites similar responses in cells that are distant from the primary insult which results in
systemic inflammation that can cause organ malfunction and shock
main causes of shock
hypoperfusion and inflammation
what must be assed in a pt w total body cellular malfunction
circulation of oxygen delivery and state of inflammation for cell toxicity
determinants of ventricular function
preload, after load, contractility, heart rate
preload
magnitude of myocardial stretch; stimulus to muscle contraction described by Frank-Starling mechanism
inc myocardial stretch leads to inc contraction which leads to
muscle being overstretched
preload is most appropriately measured as
end diastolic volume
after load is determined by
resistance to ventricular ejection that is present in either the pulmonary (pulmonary vascular resistance) or systemic arterial tree (systemic vascular resistance); inc by obstruction or vascular constriction
what is heart rate directly proportional to
cardiac output
initial response to tissue damage by trauma
bleeding and coagulation
hypoperfusion
dec in total body or regional blood flow that is sufficient to result in cellular malfunction or death
neurohumoral response to hypoperfusion
tachycardia (epinephrine, norepinephrine, dopamine), vasoconstriction (norepinephrine, arginine vasopressin, angiotensin), diaphoresis (norepinephrine), oliguria with sodium and water conservation (adrenocorticotropic hormone [ACTH], Cortisol, aldosterone, arginine vasopressin), and hyperglycemia (epinephrine, glucagon, Cortisol, insufficient insulin)
reperfusion injury
myocardial impairment, usually with arrhythmia, following the opening of arterial blockage and considered to be due to oxygen derived free radicals
classic effect of hypo perfusion on cellular metabolism
anaerobic metabolism caused by an oxygen deficit
primary etiologies of hypo perfusion states in surgical patients
dec venous return and dec myocardial function
mc cause of dec venous return secondary to dec MSP
hypovolemia (inflam, infx, trauma, pancreatitis, burns, vomiting,diuresis, inad oral intake)
s/sx of hypovolemic hypoperfusion
agitation, tachypnea, peripheral vasoconstriction
labs for hypovolemic hypoperfusion
serum electrolytes, arterial blood gases, blood lactic acid concentration; BUN/Cr