SM45_Quantitative

Question 1

The amount of a drug removed per unit time (mg/hr)

Answer 1

rate of elimination

Question 2

The volume of plasma that gets cleared of a drug per unit time (ml/min)

Answer 2

Clearance

Question 3

rate of elimination (mg/hr) / concentration (mg/mL)

Answer 3

Equation for Clearance

Question 4

In a first order drug elimination, _____ is constant but the _______ changes. The system is saturated or nonsaturated?

Answer 4

t-1/2 is constant, rate of elimination changes; system is nonsaturated

Question 5

In zero order drug elimination, ____ is constant but ____ is unpredictable. The system is saturated/non-saturated?

Answer 5

rate of elimination is constant, t-1/2 is unpredictable, system is saturated

Question 6

It will take _____ half-lives for a drug to reach its 90% of the eventual steady state concentration

Answer 6

3.3

Question 7

For an drug administered on a regular constant schedule, we will not see the full therapeutic effect for ____ times the half life

Answer 7

3.3

Question 8

Loading Dose

Answer 8

Question 9

Maintenance Dose

Answer 9

Question 10

To achieve the target concentration quickly and then to alos maintain it, we would develop / find the _______ and ______

Answer 10

loading dose and maintenance infusion/dose

Question 11

We can adjust the maintenance dose based on what factors?

Answer 11

factors that may affect clearance mechanisms, such as disease, genetics, or drug interactions

Question 12

We can adjust loading dose based on what factors?

Answer 12

Factors that affect Vd, such as age, weight, and sex