SM 218a - Cartilage Histology Flashcards
Which cells produce the matrix that makes up cartilage?
Chondrocytes
What is the role of hyaluronic acid in the extracellular matrix?
Hyaluronic acid = larges glycosaminoglycan in the matrix
- Forms complexes with negative charges
- Binds with water to give the matrix viscosity, strength, and flexibility
Where i shyaline cartilage found?
- Respiratory tube
- Costal cartilage
- Cartilage in the nose
Which number labels a lacunar space?
1
https://peir-vm.path.uab.edu/wsi.php?slide=UAB-Histology-00002
What structure does #4 indicate?
Interterritorial matrix
https://peir-vm.path.uab.edu/wsi.php?slide=UAB-Histology-00002
What structure does #3 indicate?
Territorial matrix
https://peir-vm.path.uab.edu/wsi.php?slide=UAB-Histology-00002
What are the 3 types of cartilage?
Describe the composition of each
-
Hyaline cartilage
- Collagen - Type II is the most abundant
- Proteoglycans
- Chondrocytes
-
Elastic cartilage
- Has elastic fibers within the matrix
-
Fibrocartilage
- Has Type I collagen fibers running through the matrix
Which of the followign would be present in the meniscus but not in the trachea?
- Bands of Type I collagen
- Elastic fivers
- Type II collagen
- Hyaluronic acid
- Water
A. Bands of Type I collagen
- Meniscus
- Fibrocartilage; contains bands of Type I collagen
- Trachea
- Hyaline cartilage; no type I collagen or elastic fibers
-
All cartilage
- Type II collagen, hyaluronic acid, and water
Where is fibrocartilage found?
- Intervertebral discs
- Meniscus
What kind of cartilage is this?
(Two different stains shown)
Elastic cartilage
(Elastic stains show elastic fibers in black)
https://peir-vm.path.uab.edu/wsi.php?slide=UAB-Histology-00111
What kind of cartilage is this?
Hyaline cartilage
Which type of cartilage is most prevalent in the human body?
Hyaline
What is the difference between territorial and Interterritorial matrix?
- Territorial
- Newer
- Found near chondrocytes
- Darker staining
- Interterritorial
- More mature
- Found further away from chondrocytes
- Lighter staining
Where is elastic cartilage found?
- Epiglottis
- External ear cartilage
What structure does #2 indicate?
Chondrocyte
https://peir-vm.path.uab.edu/wsi.php?slide=UAB-Histology-00002
Chondrocytes are found in _____ spaces
Chondrocytes are found in lacunar spaces
Which kind of cartilage has a “herringbone pattern?”
Fibrocartilage
Found in intervertebral disks and the meniscus
Describe the composition of cartilage
Cartilage = Chondrocytes + Surrounding matrix
-
Matrix
- Water + Collagen + Proteoglycans + Glycosaminoglycans
- Collagen is mostly type II
- Most importatn glycosaminoglycan is
- *hyaluronic acid**
What are the functions of cartilage?
- Support the body
- Articulate joints
- Provide attachment sites for muscles
- Improve flexibility
- Act as a scaffold for bone development
What type of cartilage comprises the meniscus?
Fibrocartilage
What type of tissue is cartilage?
Connective tissue
What kind of cartilage is this?
Fibrocartilage
- Alternating layers in a herringbone pattern
- Collagen runs though the layers giving fibrocartilage resistance to compressive forces (ex: in intervertebral discs)
http://virtualslides.med.umich.edu/Histology/Basic%20Tissues/Cartilage%20and%20Bone/045_HISTO_40X.svs/view.apml?cwidth=817&cheight=1021&chost=virtualslides.med.umich.edu&csis=1&X=0&Y=0&zoom=4.09417768499188&listview=1
What structure does #5 indicate?
Isogenous groups
https://peir-vm.path.uab.edu/wsi.php?slide=UAB-Histology-00002
Collagen running through fibrocartilage in layers gives the intervertebral disk resistance to __________ forces
Collagen running through fibrocartilage in layers gives the intervertebral disk resistance to compressive forces
