Slide 9 JP skin Flashcards
1
Q
The keratin layer is like a brick wall where the bricks are _________ and the cement is ________
A
The keratin layer is like a brick wall where the bricks are Corneocytes and the cement is interceullular lipids
2
Q
How many cells thick is the stratum corneum ?
A
Typically 20 cells thick
3
Q
What holds adjacent corneoytes together?
A
Corneodesmosomes
4
Q
What is ficks law of the rate of absorption?
A
Flux = Permeability coefficient x concentration of drug in the vehicle
5
Q
What is the permeability coefficient ?
A
Permeability coefficient = (partition coefficient x diffusion coefficient) / length of diffusion pathway)
