Slide 9 JP skin Flashcards

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1
Q

The keratin layer is like a brick wall where the bricks are _________ and the cement is ________

A

The keratin layer is like a brick wall where the bricks are Corneocytes and the cement is interceullular lipids

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2
Q

How many cells thick is the stratum corneum ?

A

Typically 20 cells thick

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3
Q

What holds adjacent corneoytes together?

A

Corneodesmosomes

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4
Q

What is ficks law of the rate of absorption?

A

Flux = Permeability coefficient x concentration of drug in the vehicle

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5
Q

What is the permeability coefficient ?

A

Permeability coefficient = (partition coefficient x diffusion coefficient) / length of diffusion pathway)

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