Sleep stuff Flashcards

1
Q

penile erections

A

REM sleep

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2
Q

Easily awakened with hypnic myoclonia

A

Stage 1 NREM

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3
Q

periods of muscle tone and relaxation

A

stage 2 NREM sleep

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4
Q

enerusis, somnambulance, night terrors

A

stage 3-4 NREM

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5
Q

deeper levels of mental functioning occur

A

stage 3-4 NREM

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6
Q

strengthens immune system

A

stage 3-4 NREM

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7
Q

time of mending for repairing and regenerating muscle

A

stage 3-4 NREM sleep

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8
Q

delta wave sleep

A

Stage 3-4 NREM

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9
Q

disoriented w amneisa if woken in this stage

A

Stage 3-4 NREM

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10
Q

constant waking during this stage may cause immunodeficiency conditions

A

stage 3-4 NREM

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11
Q

what stage is increased physiologic activity

A

RR, BP, HR
spontaneous penile erections
REM Sleep

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12
Q

what stage is near total paralysis of muscles

A

REM sleep

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13
Q

low serotonin

A

less sleep

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14
Q

more NE

A

less sleep

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15
Q

more melatonin

A

more sleep

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16
Q

more dopamine

A

less sleep

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17
Q

at what age is Stage 4 NREM nearly absent by

A

70

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18
Q

What is the diagnostic criteria for insomnia?

A

1+ of the following for 1 month:
* Difficulty initiating/maintaining sleep
* Nonrestorative or poor quality sleep
* Early morning awakening

Symptoms occur DESPITE adequate opportunity/circumstances for sleep
Impaired sleep producing daytime function deficits

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19
Q

Decreased REM, decreased sleep latency, increased stage 1, increased wakefullness

A

alcohol abuse effects on sleep

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20
Q

Consider TCA’s or anxiolytics (benzos) for the SE of sedation and somnolence…

A

secondary insomnia

primarily you want to treat underlying cuase

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21
Q

first line Tx for insomnia

A

CBT

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22
Q

what are the OTC 1st gen antihistamines

A

Benadryl
doxylamine

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23
Q

what are the benzo receptor agonists

A

sonata
ambien
lunesta

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24
Q

what are the melatonin agonists

A

melatonin OTC, ramelteon/rozerem

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25
Q

what are the benzos used for insomnia

A

restoril (remazepam)
fluazepam (dalmane)

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26
Q

what are the dual orexin receptor antagonists

A

all end in orexin

27
Q

what antidepressents do we use in insomniacs

A

doxepin (TCA)
trazodone (zzzzzzz)
mirtazapine/remeron

28
Q

what insomnia drug is preferred in pregnancy

A

doxylamine

29
Q

what drug is avoided in obese patients

A

mirtazapine/remeron

30
Q

occurs for 3+ months at least 2-6 times/day

A

narcolepsy

31
Q

Multiple sleep latency test

A

narcoolepsy diagnosis

32
Q

Treated with modafinil, methylphenidate or dextroamphetamine

A

these are stimulant drugs used in narcolepsy

also treated w SSRIs/SNRIs and forced naps

33
Q

treated w SSRIs/SNRIs and forced naps

A

narcolepsy

also treated w modafinil, methylphenidate or dextroamphetamine (stimlulants)

34
Q

Risk factors of sleep deprivation, GERD, sleep apnea and acute stress

A

somnambulism

35
Q

what phase of sleep does bruxism occur

A

NREM sleep

36
Q

pt has headaches and TMJ, what sleep disorder do they likely have

A

bruxism

37
Q

is advanced sleep phase type more common in younger patients or elderly

A

elderly

38
Q

what patients have non-24 hour sleep wake rhythm type circadian rhythm disorders

A

blind paients

39
Q

what type of patients are likely to have irregulat sleep-wake circadian rhythm disorder

A

developmental issues with children

40
Q

how to treat advanced sleep circadian rhythm disroder

A

bright liht in evening

41
Q

what are the pharm treatments for circadian rhythm disorders

A

melatonin (resynchronize)
stimulants (caffeine and modafinil)

42
Q

sleep apnea criteria

A

breath cessation for 10 seconds

43
Q

hypopnea criteria

A

decreased airflow resultsing >4% decrease in O2

44
Q

central sleep apnea

A

Absent ventilatory effort throughout episode

45
Q

obstructive sleep apnea

A

Persistent ventilatory effort but obstructed

46
Q

mixed sleep apnea

A

Absent ventilatory effort precedes the obstruction

47
Q

RV dysfunction

A

obstructive sleep apnea

48
Q

overnight polycomnography

what for and what include

A

obstructive sleep apnea

includes EEG, electrooculography, EMG, EKG, pulse ox, and end tidal co2 monitoring

49
Q

sinus arrest or AV block may occur

A

bradydysrhythmias in sleep apnea

50
Q

paroxysmal SVT or v tach

A

tachydysrhythmias in sleep apnea

51
Q

Facilitate GABA-mediated inhibition of cell firing

A

MOA of a benzo receptor agonist

52
Q

stage 1 NREM sleep reduction, decrease in REM, does not reduce stage 3.

what med

A

benzo receptor agonist

53
Q

benzo receptor agonist w short half life that is not indicated in long term use

A

zaleplon/sonata

54
Q

BBW for no use in complexsleep related disorders

A

benzo receptor agonistrs

55
Q

avoid with grapefruit juice, meals, sedatives

A

ambien

56
Q

good sleep onset and sleep maintenance insomnia medication

A

ambien and lunesta

57
Q

good sleep onset med, bad sleep maintenance med

A

sonata
ramelteon/rozerem

58
Q

benzo receptor agonist w longest half life

A

lunesta

59
Q

desensitized receptors can occur with chronic use of this med

A

melatonin

60
Q

avoid w coumadin and hypotension

A

OTC melatonin

61
Q

avoid use w fluvoxamine/luvox

A

ramelteon/rozerem

62
Q

interacts w CYP3A4

A

orexin receptor antagonists

63
Q

requires dose adjustment for elderly

A

daridorexant

64
Q

only schedule 3 drug in sleep lecture and why

A

sodium oxybates, date rape drug.

strong CNS depressant