ADHD thiings Flashcards
what is the MOA of ADHD
decreased catecholamines in the synapse
What is the DSM-TV-R criteria for an ADHD diagnosis?
6+ symptoms from at least one category (inattentive or hyperactive) for at least 6+ months)
* Maladaptive and INCONSISTENT with developmental level.
* Some symptoms must be present prior to age 12.
* CLEAR FUNCTIONAL IMPAIRMENT IN 2+ SETTINGS. (home and school)
What medications fall under methylphenidates
Ritalin
Focalin
Concerta
Quillivant
What medications fall under amphetamines?
Adderall
Vyvanse
Methylphenidate MOA
block reuptake of catecholamines
amphetamine MOA
block reuptake of catecholamines and stimulate dopamine release
Why is XR ideal formualtion for stimulatns
reduce adverse SE at the peak and reducing the crash at trough.
Reduces tachyphylaxis (reducing rapid tolerance)
priapism
methylphenidates
MAOI use, glaucoma, severe CVD, tourettes, hyperthyroidism
CI for stimulants
which stimulant is used more in preschool age
methylphenidates
What is the MOA of atomoxetine?
SNRI. (Not a controlled substance)
dyspepsia, hepatotoxicity
SE of atomoxetine
also has:
CVD
priapism
psychosis/SI
NV ab pain, weight loss, dec appetite
MAOI use, glaucoma, severe CVD, pheochromocytoma
CI for atomoxetine
what is first line, second line, third line, and fourth line pharm options for ADHD
- sitmulants
- amoxetine
- alpha 2 andrenergic agonists
- TCAs
what are the 2 alpha 2 adrenergic agonists
XR clonidine
XR guanfacine