ADHD thiings Flashcards
what is the MOA of ADHD
decreased catecholamines in the synapse
What is the DSM-TV-R criteria for an ADHD diagnosis?
6+ symptoms from at least one category (inattentive or hyperactive) for at least 6+ months)
* Maladaptive and INCONSISTENT with developmental level.
* Some symptoms must be present prior to age 12.
* CLEAR FUNCTIONAL IMPAIRMENT IN 2+ SETTINGS. (home and school)
What medications fall under methylphenidates
Ritalin
Focalin
Concerta
Quillivant
What medications fall under amphetamines?
Adderall
Vyvanse
Methylphenidate MOA
block reuptake of catecholamines
amphetamine MOA
block reuptake of catecholamines and stimulate dopamine release
Why is XR ideal formualtion for stimulatns
reduce adverse SE at the peak and reducing the crash at trough.
Reduces tachyphylaxis (reducing rapid tolerance)
priapism
methylphenidates
MAOI use, glaucoma, severe CVD, tourettes, hyperthyroidism
CI for stimulants
which stimulant is used more in preschool age
methylphenidates
What is the MOA of atomoxetine?
SNRI. (Not a controlled substance)
dyspepsia, hepatotoxicity
SE of atomoxetine
also has:
CVD
priapism
psychosis/SI
NV ab pain, weight loss, dec appetite
MAOI use, glaucoma, severe CVD, pheochromocytoma
CI for atomoxetine
what is first line, second line, third line, and fourth line pharm options for ADHD
- sitmulants
- amoxetine
- alpha 2 andrenergic agonists
- TCAs
what are the 2 alpha 2 adrenergic agonists
XR clonidine
XR guanfacine
SE of sedation and hypotension
XR clonidine
Cardiotoxicity SE
TCAs
Child has ADHD but also comorbid psych disorder… what could be used?
TCA
used to reduce aggressiveness and hyperactivity
bupropion
blocks reuptake of NE and dopamine MOA
bupropion
M-CHAT-R/F
modified checklist for autism in toddlers
treatment for maladaptive behaviors in ASD
SSRIs, alpha-andrenergics, antipsychotics
SSRI - specifically risperidone and aripiprazole
treatment for anxiety/depression/dysregulated mood in ASD
SSRIs
treatment for hyperactivity/inattentiveness in ASD
stimulatns
mutation of MECP2 gene
rett syndrome - causes growth deceleration of brain tissue
Baby shows deceleration of head growth at 2 months
rett syndrome
at 14 months, baby Rosa stops using fine motor skills and stops using words that she previously said consistently
rett syndrome
deceleration of communication and fine motor skills
what are the 2 alpha 2 adrenergic agonists
XR clonidine
XR guanfacine
