Sleep Physiology Flashcards

1
Q

Describe non-REM sleep

A

3/4 adults sleep, at start of the night. Synchronised rhythmic EEG activity with partial relaxation of muscles - reduced cerebral blood flow, heart rate, BP and tidal volumes. Non- narrative dreams.

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2
Q

Describe REM sleep

A

Mostly at the end of the night, EEG shows fast activity with increased brain activity. Atonic muscles - except diaphragm and extraocular muscles. Increased blood flow and impaired thermal regulation - narrative dreaming

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3
Q

What is the most important type of sleep?

A

Non-REM, if sleep deprived non-REM will be predominant in recovery

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4
Q

What type of drug suppresses REM sleep?

A

Tricyclics

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5
Q

Name three processes involved in sleep

A
  • homeostatic response
  • emotional response
  • circadian rhythm
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6
Q

What is homeostatic response involved in sleep onset?

A

Longer you are awake for the more sleepy you feel

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7
Q

What is emotional response in sleep onset?

A

Need to be relaxed and comfortable enough to sleep

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8
Q

What is circadian rhythm?

A

Body clock - 2 peak pattern, important in appetite and hormone secretion, 25 hours, impacted by light

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9
Q

How does light affect our body clocks?

A

Non-rod, non-cone ganglion cells project to the suprachiasmatic nucleus sensitive to a specific frequency of blue light - re-sets your body clock each day

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10
Q

What important processes occur in non-REM sleep?

A

Protein synthesis

Cell division and growth

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11
Q

What important processes are involved in REM sleep?

A

Consolidated memory, deletion of unnecessary memory files, immunocompetence maintenance, thermoregulation and conservation theory

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12
Q

State the prefrontal effects of lack of sleep

A
  • irritable
  • suspicious
  • visual illusions
  • concentration lapses
  • microsleeps
  • impaired alertness
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13
Q

What is an acceptable amount of sleep?

A

7-7.5 hours

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14
Q

Name three sleep disorders

A
  • parasomnias
  • narcolepsy
  • insomnia
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15
Q

What are parasomnias?

A

Wakening with no memory

  • sleep walking, talking, restless legs - non-REM
  • no loss of muscle tone, simple behaviours in latter third of night -REM
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16
Q

What causes parasomnias?

A

Usually idiopathic but REM parasomnias can be a sign of parkinsons or dementias

17
Q

What is narcolepsy?

A

‘Seized by somnolence’

18
Q

What are the symptoms of narcolepsy?

A
  • Daytime sleepiness
  • Cataplexy - loss of muscle tone in emotion
  • Hypnagogic hallucinations (as you fall asleep)
  • Sleep paralysis
  • REM behaviour disorder
19
Q

State the investigations used in narcolepsy

A

Overnight polysomnography

Multiple sleep latency test - multiple naps with EEG muscle recording, very quickly enter REM sleep

20
Q

In the first three months of insomnia what can be used as treatment?

A

Benzodiazapines

21
Q

What is it called after 3 months of insomnia? How can it be treated?

A

Psychophysiological, brain becomes more active when they try to sleep - remove bad habits and use sleep deprivation methods