Sleep Disorders Flashcards

1
Q

What are the stages of sleep?

A

Non-REM (N1, N2, N3) and REM

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2
Q

When you are awake with your eyes open, your EEG will show low amplitude, high frequency waves called

A

Beta waves

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3
Q

Low amplitude, high frequency waves

A

Beta waves

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4
Q

If you are awake with eyes closed, your EEG will pick up

-Increased amplitude

A

Alpha waves

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5
Q

Considered to be the lightest sleep (easy to wake) and is comprised of theta waves

A

N1

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6
Q

The smallest percentage of sleep time

A

N1

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7
Q

Also made up of theta waves and makes up the largest percentage of sleep time

A

N2

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8
Q

A sudden increase in amplitude of N2 waves

A

K complexes

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9
Q

A sudden increase in frequency in N2 complexes

A

Sleep spindles

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10
Q

The last phase before REM sleep

-Made up of delta waves

A

N3

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11
Q

The deepest sleep, I.e. hardest to wake from

-Where we see sleep walking, sleep talking, and bed wetting

A

N3

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12
Q

Rapid eye movements originating from the PPRF

-Low voltage pattern that often appears saw-toothed

A

REM sleep

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13
Q

During REM sleep we have a loss of

A

Motor tone

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14
Q

Dreaming, nightmares, and penile tumescence occurs during

A

REM sleep

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15
Q

Sleep goes through cycles during the night. One cycle from NREM to REM is about

A

90 minutes

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16
Q

During cycles, the length of REM

A

Increases

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17
Q

During cycles, the length of N3

A

Decreases

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18
Q

N3 and REM sleep % is decreased by

A

Sedative drugs (alcohol, benzos, and barbituates)

19
Q

REM starts quicker after sleep onset with

-Decreased REM sleep latency

A

Depression

20
Q

Has an increase in total REM sleep with a decrease in slow-wave N3 sleep

A

Depression

21
Q

Undesirable physical events and unwanted experiences that occur during sleep

A

Parasomnias

22
Q

Disorders of arousal during sleep

-Occur during non-REM sleep

A

NREM disorders

23
Q

NREM disorders usually occur in

24
Q

Sleepwalking, sleep terrors, and sleep-related sting disorders are forms of

A

NREM disorders

25
How can we treat NREM disorders and what is the affect?
Benzodiazepines (decrease N3 sleep)
26
Neurological disorder of sleep-wake cycles - Sleep during wakefulness - Wakefulness during sleep
Narcolepsy
27
Narcolepsy causes excessive
Daytime sleepiness
28
Caused by decreased neuropeptides in the lateral hypothalamus
Narcolepsy
29
What are the two neuropeptides that are decreased in Narcolepsy?
Orexin-A (hypocretin-1) and Orexin B (hypocretin-2)
30
Not tired when waking in the morning -Fall asleep during the day, often at inappropriate times
Narcolepsy
31
Sudden loss of muscle tone, usually affecting the face, neck, or knees
Cataplexy
32
Muscle weakness that may lead to collapse, but with NO loss of consciousness (contrast w/ syncope)
Cataplexy
33
Cataplexy is triggered by
Strong emotions
34
Hallucinations usually occur when falling asleep, in other words they are
Hypnagogic
35
Hallucinations that occur when awakening are called
Hypnopompic
36
Inability to move after awakening for 1-2 minutes -Caused by REM sleep while awake
Sleep paralysis
37
Sleep paralysis may occur concomitantly with
Hallucinations
38
When orexin neurons are killed by an autoimmune process, we see
Narcolepsy
39
Narcolepsy is strongly associated with
HLA DQB1
40
A controlled substance that promotes wakefulness and is used to treat narcolepsy
Modafinil
41
Indirect sympathomimetics that increase dopamine and norepinephrine CNS levels -Used to treat Narcolepsy and ADHD
Methylphenidate and amphetamines
42
Salt form of gamma-hydroxybutyrate (GHB), a GABA analogue
Sodium oxybate
43
A CNS depressant that is used to treat narcolepsy with the main benefit of reducing cataplexy
Sodium oxybate
44
The illegal version of GHB is the
Date rape drug